Factors in Homo and Heterotypic Aggregate Formation in Sepsis

Sepsis, a severe systemic inflammatory response to an infection that can be bacterial, viral or fungal in origin, remains a serious condition with high mortality. The dynamics in the immune response (immune activation, over activation and exhaustion) during development and progression of sepsis pose a problem in the design of new treatment approaches. This review focuses on the understanding of molecular interactions that lead to the formation of cellular aggregates in sepsis and puts novel treatment targets in the context of these interactions.