A novel segmentation framework using sparse random feature in histology images of colon cancer

In this paper, we present a novel segmentation framework for glandular structures in Hematoxylin and Eosin stained histology images, choosing poorly differentiated colon tissue as an example. The proposed framework’ target is to identify precise epithelial nuclei objects. We start with staining separate to detect all nuclei objects, and deploy multi-resolution morphology operation to map the initial epithelial nuclei positions. We proposed a new bag of words scheme using sparse random feature to classify epithelial nuclei and stroma nuclei objects to adjust the rest nuclei positions. Finally, we can use the boundary of optimized epithelial nuclei objects to segment the glandular structure.