Combining a novel electrical restitution based biomarker with heart rate variability analysis improves prediction of sudden cardiac death risk

Sudden cardiac death (SCD) remains a significant cause of mortality worldwide. Current SCD risk markers have substantial limitations. Peak Electrical Restitution Slope (PERS) is a promising new SCD risk marker. PERS uses the surface 12-lead ECG to measure peak restitution gradient, a property of myocardium known to play a role in ventricular arrhythmogenesis. By combining PERS with heart rate variability (HRV) analysis, we sought to improve SCD risk prediction in patients with ischaemic cardiomyopathy (ICM).