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Prenatal, early-life and childhood exposure to air pollution and lung function in the UK Avon Longitudinal Study of Parents and Children (ALSPAC) cohort

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posted on 2020-05-13, 11:59 authored by Anna Hansell, Yutong Cai, Raquel Granell, Marta Blangiardo, Daniela Fecht, John Gulliver, John Henderson, Paul Elliott

Rationale: This study investigated asssociations of source-specific air pollution exposure during pregnancy trimesters, infancy and childhood in relation to lung function at ages eight and 15 years in ~14,000 children.

Methods: Individual exposure to primary road, local and long range particulate matter with diameter ≤10µm (PM10) were estimated using dispersion modelling for each pregnancy trimester, ages 0-6 months, 7-12 months (1990-1993) and annually to age 15 years (1991-2008). Forced expiratory volume in one second (FEV1) and forced vital capacity (FVC) were measured at age eight and 15 years and converted into age-height-gender adjusted z-scores. Linear regression analyses were conducted, adjusting for potential confounders.

Results: 13,963 study children were included in the analysis. At age 8 years, exposure to interquartile range (IQR) higher primary PM10 (0.72µg/m3) from road traffic during the first trimester was associated with lower FEV1 (-0.049, 95%CI:-0.082 to -0.016) and FVC (-0.048, 95%CI:-0.081 to -0.015) z-scores. Similar associations were also seen for exposures during the second and third trimester, and during 0-6 months, 7-12 months, and 0-7 years. Associations were stronger among boys, children whose mother had a lower education level or smoked in pregnancy. PM10 from all sources during the third trimester was significantly associated with lower FVC z-scores. No significant negative associations were seen at age 15 years.

Conclusions: Exposure to road-traffic PM10 from as early as in the first trimester may result in small but significant reductions in lung function at age eight years.

Funding

This research was funded by the UK Medical Research Council (grant number: G0700920). The UK Medical Research Council and Wellcome (grant number: 102215/2/13/2) and the University of Bristol provide core support for ALSPAC. The Medical Research Council Centre for Environment and Health is funded by the UK Medical Research Council (grant number MR/S019669/1). Y.C was supported by a MRC Early-Career Research Fellowship awarded through the MRC Centre for Environment and Health (grant number MR/M501669/1).P.E. acknowledges funding from the National institute for Health Research (NIHR) Imperial Biomedical ResearchCentre, the NIHR Health Protection Research Unit in Health Impact of Environmental Hazards (HPRU-2012-10141) and the UK Dementia Research Institute supported by UK DRI Ltd which is funded by the UK Medical Research Council, Alzheimer’s Society and Alzheimer’s Research UK. P.E. is associate director of Health Data Research UK-London which receives funding from a consortium led by the UK Medical Research Council.

History

Citation

Anna Hansell, Yutong Cai, Raquel Granell, Marta Blangiardo, Daniela Fecht, John Gulliver, John Henderson, Paul Elliott European Respiratory Journal 2019 54: OA482; DOI: 10.1183/13993003.congress-2019.OA482

Source

European-Respiratory-Society (ERS) International Congress

Version

  • AM (Accepted Manuscript)

Published in

EUROPEAN RESPIRATORY JOURNAL

Volume

54

Issue

suppl 63

Pagination

OA482 (2)

Publisher

EUROPEAN RESPIRATORY SOC JOURNALS LTD

issn

0903-1936

eissn

1399-3003

Copyright date

2019

Available date

2019-11-21

Publisher version

https://erj.ersjournals.com/content/54/suppl_63/OA482.abstract

Spatial coverage

Madrid, SPAIN

Temporal coverage: start date

2019-09-28

Temporal coverage: end date

2019-10-02

Language

en

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