Data for "Anti-Breast Cancer Stem Cell Activity of Titanocene Complexes of Non-Steroidal Anti-Inflammatory Drugs"
dataset
posted on 2025-09-16, 08:03 authored by Olympia Mouriki, Ginevra Passeri, Karampal Singh, Sarah D. Lamorte, Kuldip Singh, Kogularamanan SuntharalingamKogularamanan Suntharalingam, Sandy KilpatrickSandy Kilpatrick<p dir="ltr">Titanocene(IV)-NSAID complexes Cp<sub>2</sub>Ti(mefenamate)<sub>2</sub> (<b>4</b>) and Cp<sub>2</sub>Ti(flufenamate)<sub>2</sub> (<b>5</b>) show enhanced redox stability and potent cytotoxicity against breast cancer stem cells (CSCs), with <b>5</b> rivaling salinomycin and cisplatin. Complex <b>5</b> induces DNA damage and apoptosis, and its nanoparticle encapsulation improves biocompatibility. This is the first report targeting breast CSCs with titanocene-based metallodrugs.</p>
Funding
EP/Y002695/1
Stopped-Flow NMR Spectroscopy for the Physical and Life Sciences
Engineering and Physical Sciences Research Council
Find out more...Single crystal X-ray diffractometer
Engineering and Physical Sciences Research Council
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