Supplemental Material for AJP-RICP paper 00140-2025 The influence of dynamic autoregulation efficiency on its directional sensitivity.

<p dir="ltr">Supplemental Material file to support article in Am J Physiol Regul Integr Comp Physiol 00140-2025 titled: The influence of dynamic cerebral autoregulation on its directional sensitivity.</p><p dir="ltr">Dynamic cerebral autoregulation (dCA), maintains cerebral blood flow approximately constant in response to rapid changes in arterial blood pressure (ABP). dCA has been shown to have better efficiency when responding to increases in ABP, compared to drops in ABP, a phenomenon named 'directional sensitivity'. In this study, we demonstrated that directional sensitivity is dependent on the efficiency of dCA, as expressed by the Autoregulation Index (ARI), but in a manner that is both sex and age dependent.</p>