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Reason: Permanent embargo on VOR

# A Mathematical Formula to Determine the Minimum Continuous Glucose Monitoring Duration to Assess Time-in-ranges: Sensitivity Analysis Over the Parameters

journal contribution
posted on 2022-03-08, 11:28 authored by N Camerlingo, M Vettoretti, G Sparacino, A Facchinetti, JK Mader, P Choudhary, S Del Favero
In diabetes management, the fraction of time spent with glucose concentration within the physiological range of [70-180] mg/dL, namely time in range (TIR) is often computed by clinicians to assess glycemic control using a continuous glucose monitoring sensor. However, a sufficiently long monitoring period is required to reliably estimate this index. A mathematical equation derived by our group provides the minimum trial duration granting a desired uncertainty around the estimated TIR. The equation involves two parameters, pr and α, related to the population under analysis, which should be set based on the clinician's experience. In this work, we evaluated the sensitivity of the formula to the parameters.Considering two independent datasets, we predicted the uncertainty of TIR estimate for a population, using the parameters of the formula estimated for a different population. We also stressed the robustness of the formula by testing wider ranges of parameters, thus assessing the impact of large errors in the parameters' estimates.Plausible errors on the α estimate impact very slightly on the prediction (relative discrepancy < 5%), thus we suggest using a fixed value for α independently on the population being analyzed. Instead, pr should be adjusted to the TIR expected in the population, considering that errors around 20% result in a relative discrepancy of ~10%.In conclusion, the proposed formula is sufficiently robust to parameters setting and can be used by investigators to determine a suitable duration of the study.

## Citation

2021 43rd Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC), IEEE Xplore, DOI: 10.1109/EMBC46164.2021.9630689

## Author affiliation

Diabetes Research Centre, College of Life Sciences

## Source

2021 43rd Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC), 1-5 Nov. 2021, Mexico

## Version

• VoR (Version of Record)

## Published in

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference

2021

1435 - 1438

IEEE

2375-7477

2694-0604

## isbn

978-1-7281-1179-7

2021

eng

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