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A TMA de-arraying method for high throughput biomarker discovery in tissue research.

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posted on 2012-10-24, 08:56 authored by Y. Wang, K. Savage, C. Grills, A. McCavigan, J. A. James, D. A. Fennell, P. W. Hamilton
Tissue MicroArrays (TMAs) represent a potential high-throughput platform for the analysis and discovery of tissue biomarkers. As TMA slides are produced manually and subject to processing and sectioning artefacts, the layout of TMA cores on the final slide and subsequent digital scan (TMA digital slide) is often disturbed making it difficult to associate cores with their original position in the planned TMA map. Additionally, the individual cores can be greatly altered and contain numerous irregularities such as missing cores, grid rotation and stretching. These factors demand the development of a robust method for de-arraying TMAs which identifies each TMA core, and assigns them to their appropriate coordinates on the constructed TMA slide.

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Citation

PLOS ONE, 2011, 6 (10), p. e26007

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  • VoR (Version of Record)

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PLOS ONE

Publisher

Public Library of Science

eissn

1932-6203

Copyright date

2011

Available date

2012-10-24

Publisher version

http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0026007

Language

eng

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