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A big STEP for treatment of heart failure with preserved ejection fraction

journal contribution
posted on 2023-10-06, 09:51 authored by Subodh Verma, Barry A Borlaug, Javed Butler, Melanie J Davies, Dalane W Kitzman, Mark C Petrie, Sanjiv J Shah, Nitish K Dhingra, Mikhail N Kosiborod
In the STEP-HFpEF trial, 2.4 mg semaglutide produced marked improvements in heart failure-related symptoms, physical limitations, and exercise function, and reduced inflammation and body weight in individuals with obesity HFpEF phenotype. These data usher in a new paradigm of targeting obesity as a therapeutic strategy in HFpEF.

History

Version

  • VoR (Version of Record)

Published in

Cell metabolism

Volume

35

Issue

10

Pagination

1681-1687

Publisher

Elsevier BV

issn

1550-4131

eissn

1932-7420

Copyright date

2023

Publisher DOI

Spatial coverage

United States

Language

eng

Publisher version

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