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A comparison of behavioral and pharmacological interventions to attenuate reactivated fear memories

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posted on 2018-02-01, 11:38 authored by Roque I. Ferrer Monti, Joaquin M. Alfei, Matias Mugnaini, Adrian M. Bueno, Tom Beckers, Gonzalo P. Urcelay, Victor A. Molina
Two experiments using rats in a contextual fear memory preparation compared two approaches to reduce conditioned fear: (1) pharmacological reconsolidation blockade and (2) reactivation-plus-extinction training. In Experiment 1, we explored different combinations of reactivation-plus-extinction parameters to reduce conditioned fear and attenuate reacquisition. In Experiment 2, memory reactivation was followed by extinction training or administration of midazolam (MDZ) (vs. vehicle) to reduce conditioned fear and attenuate spontaneous recovery. We found both treatments to be equally effective in both experiments. This study suggests that parameters leading to memory destabilization during reactivation are critical to observe long-lasting effects of MDZ or reactivation plus extinction.

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Citation

Learning and Memory, 2017, 24 (8), pp. 369-374

Author affiliation

/Organisation/COLLEGE OF LIFE SCIENCES/Biological Sciences/Neuroscience, Psychology and Behaviour

Version

  • AM (Accepted Manuscript)

Published in

Learning and Memory

Publisher

Cold Spring Harbor Laboratory Press

issn

1072-0502

eissn

1549-5485

Acceptance date

2017-05-12

Copyright date

2017

Available date

2018-02-01

Publisher version

http://learnmem.cshlp.org/content/24/8/369

Language

en

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