A dithiacyclam-coordinated silver(i) polymer with anti-cancer stem cell activity
journal contribution
posted on 2021-09-24, 15:57 authored by Alice Johnson, Linda Iffland, Kuldip Singh, Ulf-Peter Apfel, Kogularamanan SuntharalingamA cancer stem cell (CSC) active, solution stable, silver(i) polymeric complex bearing a dithiacyclam ligand is reported. The complex displays similar potency towards CSCs to salinomycin in monolayer and three-dimensional cultures. Mechanistic studies suggest CSC death results from cytosol entry, an increase in intracellular reactive oxygen species, and caspase-dependent apoptosis.
Funding
K. S. is supported by an EPSRC New Investigator Award (EP/S005544/1). U.-P. A. is supported by the DFG (AP242/5-1) and Fraunhofer Internal Programs (Attract 097-602175).
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Citation
Dalton Trans., 2021,50, 5779-5783Version
- VoR (Version of Record)
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Dalton Transactions: an international journal of inorganic chemistryVolume
50Issue
17Pagination
5779 - 5783Publisher
Royal Society of Chemistryissn
1477-9226eissn
1477-9234Acceptance date
2021-04-14Copyright date
2021Available date
2021-04-14Publisher DOI
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