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A gene-centric study of common carotid artery remodelling

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posted on 2016-03-01, 12:03 authored by S. C. Harrison, D. Zabaneh, F. W. Asselbergs, F. Drenos, G. T. Jones, S. Shah, K. Gertow, B. Sennblad, R. J. Strawbridge, B. Gigante, S. Holewijn, J. De Graaf, S. Vermeulen, L. Folkersen, A. M. van Rij, D. Baldassarre, F. Veglia, P. J. Talmud, J. E. Deanfield, O. Agu, M. Kivimaki, M. Kumari, Matthew James Bown, K. Nyyssönen, R. Rauramaa, A. J. Smit, A. Franco-Cereceda, P. Giral, E. Mannarino, A. Silveira, A. C. Syvänen, G. J. de Borst, Y. van der Graaf, U. de Faire, A. F. Baas, J. D. Blankensteijn, N. J. Wareham, G. Fowkes, I. Tzoulaki, J. F. Price, E. Tremoli, A. D. Hingorani, P. Eriksson, A. Hamsten, S. E. Humphries
BACKGROUND: Expansive remodelling is the process of compensatory arterial enlargement in response to atherosclerotic stimuli. The genetic determinants of this process are poorly characterized. METHODS: Genetic association analyses of inter-adventitial common carotid artery diameter (ICCAD) in the IMPROVE study (n = 3427) using the Illumina 200k Metabochip was performed. Single nucleotide polymorphisms (SNPs) that met array-wide significance were taken forward for analysis in three further studies (n = 5704), and tested for association with Abdominal Aortic Aneurysm (AAA). RESULTS: rs3768445 on Chromosome 1q24.3, in a cluster of protein coding genes (DNM3, PIGC, C1orf105) was associated with larger ICCAD in the IMPROVE study. For each copy of the rare allele carried, ICCAD was on average 0.13 mm greater (95% CI 0.08-0.18 mm, P = 8.2 × 10(-8)). A proxy SNP (rs4916251, R(2) = 0.99) did not, however, show association with ICCAD in three follow-up studies (P for replication = 0.29). There was evidence of interaction between carotid intima-media thickness (CIMT) and rs4916251 on ICCAD in two of the cohorts studies suggesting that it plays a role in the remodelling response to atherosclerosis. In meta-analysis of 5 case-control studies pooling data from 5007 cases and 43,630 controls, rs4916251 was associated with presence of AAA 1.10, 95% CI 1.03-1.17, p = 2.8 × 10(-3), I(2) = 18.8, Q = 0.30). A proxy SNP, rs4916251 was also associated with increased expression of PIGC in aortic tissue, suggesting that this may the mechanism by which this locus affects vascular remodelling. CONCLUSIONS: Common variation at 1q24.3 is associated with expansive vascular remodelling and risk of AAA. These findings support a hypothesis that pathways involved in systemic vascular remodelling play a role in AAA development.

History

Citation

Atherosclerosis, 2013, 226 (2), pp. 440-446

Author affiliation

/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGY/School of Medicine/Department of Cardiovascular Sciences

Version

  • VoR (Version of Record)

Published in

Atherosclerosis

Publisher

Elsevier for European Atherosclerosis Society, International Atherosclerosis Society, Society of Atherosclerosis Imaging and Prevention

issn

0021-9150

eissn

1879-1484

Acceptance date

2012-11-02

Copyright date

2012

Available date

2016-03-01

Publisher version

http://www.sciencedirect.com/science/article/pii/S0021915012007976

Language

en