A new zinc (II) responsive MRI contrast agent
journal contribution
posted on 2019-05-09, 15:26 authored by Adhitiyawarma, Mark P. LoweA new potential zinc-responsive gadolinium DO3A-based MRI contrast agent has been synthesized containing a picolinate acid group as an active arm. To study the complex properties, its emissive europium analogue has been prepared as a model. Changes in absorption and emission properties were observed as well as in the hydration number of the complex in response to increasing concentration of zinc (II). Further examination of the gadolinium complex showed a high relaxivity. In addition, a 32% modulation of relaxivity was observed in response to added zinc (II) ion which is beneficial as a zinc-responsive MRI contrast agent.
Funding
The authors thank to Dr. Gerry Griffith for NMR experiments, Mr. Mick Lee for mass spectroscopy analysis and Ministry of Research, Technology and Higher Education Directorate General of Resources for Research, Technology and Higher Education Republic of Indonesia for funding.
History
Citation
Research Journal of Chemistry and Environment, 2018, 22 (Special issue II), pp. 22-30Author affiliation
/Organisation/COLLEGE OF SCIENCE AND ENGINEERING/Department of ChemistryVersion
- AM (Accepted Manuscript)
Published in
Research Journal of Chemistry and EnvironmentPublisher
World Research Journals, Indoreissn
0972-0626eissn
2278-4527Copyright date
2018Available date
2019-05-09Publisher version
https://www.worldresearchjournal.com/chemistryhome.aspxLanguage
enAdministrator link
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