A novel high sensitivity bacteriophage based assay identifies low level M.tuberculosis bacteraemia in immunocompetent patients with active and incipient TB
journal contribution
posted on 2019-06-13, 09:22 authored by Raman Verma, Benjamin M. C. Swift, Handley-Hartill Wade, Joanne K. Lee, Gerrit Woltmann, Catherine E. D. Rees, Haldar PranabashisHaematogenous dissemination of M. tuberculosis (Mtb) is critical to pathogenesis of
progressive tuberculous infection in animal models. Using a novel phage-based blood assay,
we report the first concordant evidence in well-characterised immunocompetent human
cohorts, demonstrating associations of Mtb bacteraemia with progressive phenotypes of latent
infection and active pulmonary TB respectively.
Funding
WH-H received a Doctoral Training Partnership studentship from the Biotechnology and Biological Sciences Research Council. Reagents were supplied by PBD Biotech Ltd (Suffolk, UK). We acknowledge the NIHR Leicester Biomedical Research Centre for their support of the study at Leicester.
History
Citation
Clinical Infectious Diseases, 2019, ciz548Author affiliation
/Organisation/COLLEGE OF LIFE SCIENCES/School of Medicine/Department of Infection, Immunity and InflammationVersion
- AM (Accepted Manuscript)
Published in
Clinical Infectious DiseasesPublisher
Oxford University Press (OUP), Infectious Diseases Society of Americaissn
1058-4838Acceptance date
2019-06-13Copyright date
2019Publisher DOI
Publisher version
https://academic.oup.com/cid/advance-article/doi/10.1093/cid/ciz548/5522421Notes
The file associated with this record is under embargo until 12 months after publication, in accordance with the publisher's self-archiving policy. The full text may be available through the publisher links provided above.Language
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