Accepted Actiphage Brief Report CID Submission Manuscript.pdf (203.92 kB)
A novel high sensitivity bacteriophage based assay identifies low level M.tuberculosis bacteraemia in immunocompetent patients with active and incipient TB
journal contributionposted on 2019-06-13, 09:22 authored by Raman Verma, Benjamin M. C. Swift, Handley-Hartill Wade, Joanne K. Lee, Gerrit Woltmann, Catherine E. D. Rees, Haldar Pranabashis
Haematogenous dissemination of M. tuberculosis (Mtb) is critical to pathogenesis of progressive tuberculous infection in animal models. Using a novel phage-based blood assay, we report the first concordant evidence in well-characterised immunocompetent human cohorts, demonstrating associations of Mtb bacteraemia with progressive phenotypes of latent infection and active pulmonary TB respectively.
WH-H received a Doctoral Training Partnership studentship from the Biotechnology and Biological Sciences Research Council. Reagents were supplied by PBD Biotech Ltd (Suffolk, UK). We acknowledge the NIHR Leicester Biomedical Research Centre for their support of the study at Leicester.
CitationClinical Infectious Diseases, 2019, ciz548
Author affiliation/Organisation/COLLEGE OF LIFE SCIENCES/School of Medicine/Department of Infection, Immunity and Inflammation
- AM (Accepted Manuscript)