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Accepted Actiphage Brief Report CID Submission Manuscript.pdf (203.92 kB)

A novel high sensitivity bacteriophage based assay identifies low level M.tuberculosis bacteraemia in immunocompetent patients with active and incipient TB

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journal contribution
posted on 2019-06-13, 09:22 authored by Raman Verma, Benjamin M. C. Swift, Handley-Hartill Wade, Joanne K. Lee, Gerrit Woltmann, Catherine E. D. Rees, Haldar Pranabashis
Haematogenous dissemination of M. tuberculosis (Mtb) is critical to pathogenesis of progressive tuberculous infection in animal models. Using a novel phage-based blood assay, we report the first concordant evidence in well-characterised immunocompetent human cohorts, demonstrating associations of Mtb bacteraemia with progressive phenotypes of latent infection and active pulmonary TB respectively.

Funding

WH-H received a Doctoral Training Partnership studentship from the Biotechnology and Biological Sciences Research Council. Reagents were supplied by PBD Biotech Ltd (Suffolk, UK). We acknowledge the NIHR Leicester Biomedical Research Centre for their support of the study at Leicester.

History

Citation

Clinical Infectious Diseases, 2019, ciz548

Author affiliation

/Organisation/COLLEGE OF LIFE SCIENCES/School of Medicine/Department of Infection, Immunity and Inflammation

Version

  • AM (Accepted Manuscript)

Published in

Clinical Infectious Diseases

Publisher

Oxford University Press (OUP), Infectious Diseases Society of America

issn

1058-4838

Acceptance date

2019-06-13

Copyright date

2019

Publisher version

https://academic.oup.com/cid/advance-article/doi/10.1093/cid/ciz548/5522421

Notes

The file associated with this record is under embargo until 12 months after publication, in accordance with the publisher's self-archiving policy. The full text may be available through the publisher links provided above.

Language

en

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