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A population-based cohort study of obesity, ethnicity and COVID-19 mortality in 12.6 million adults in England

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journal contribution
posted on 2022-03-11, 15:37 authored by Thomas Yates, Annabel Summerfield, Cameron Razieh, Amitava Banerjee, Yogini Chudasama, Melanie J Davies, Clare Gillies, Nazrul Islam, Claire Lawson, Evgeny Mirkes, Francesco Zaccardi, Kamlesh Khunti, Vahé Nafilyan
Obesity and ethnicity are known risk factors for COVID-19 outcomes, but their combination has not been extensively examined. We investigate the association between body mass index (BMI) and COVID-19 mortality across different ethnic groups using linked national Census, electronic health records and mortality data for adults in England from the start of pandemic (January 2020) to December 2020. There were 30,067 (0.27%), 1,208 (0.29%), 1,831 (0.29%), 845 (0.18%) COVID-19 deaths in white, Black, South Asian and other ethnic minority groups, respectively. Here we show that BMI was more strongly associated with COVID-19 mortality in ethnic minority groups, resulting in an ethnic risk of COVID-19 mortality that was dependant on BMI. The estimated risk of COVID-19 mortality at a BMI of 40 kg/m2 in white ethnicities was equivalent to the risk observed at a BMI of 30.1 kg/m2, 27.0 kg/m2, and 32.2 kg/m2 in Black, South Asian and other ethnic minority groups, respectively.

Funding

This research was funded by a grant from the UKRI (MRC)-DHSC (NIHR) COVID-19 Rapid Response Rolling Call (MR/V020536/1) (T.Y.) and is part of the Data and Connectivity National Core Study, led by Health Data Research UK in partnership with the Office for National Statistics and funded by UK Research and Innovation (HDRUK2020.138) (T.Y., K.K.).

History

Citation

Yates, T., Summerfield, A., Razieh, C. et al. A population-based cohort study of obesity, ethnicity and COVID-19 mortality in 12.6 million adults in England. Nat Commun 13, 624 (2022). https://doi.org/10.1038/s41467-022-28248-1

Author affiliation

Diabetes Research Centre; NIHR Leicester Biomedical Research Centre

Version

  • VoR (Version of Record)

Published in

Nature Communications

Volume

13

Pagination

624

Publisher

Springer Science and Business Media LLC

eissn

2041-1723

Acceptance date

2022-01-05

Copyright date

2022

Available date

2022-03-11

Language

en

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