A reactive oxygen species-generating, cyclooxygenase-2 inhibiting, cancer stem cell-potent tetranuclear copper(ii) cluster.
journal contribution
posted on 2019-06-14, 14:41 authored by C. Lu, K. Laws, A. Eskandari, K. SuntharalingamTetranuclear copper(ii) complexes containing multiple diclofenac and Schiff base moieties, 1-4, are shown to kill bulk cancer cells and cancer stem cells (CSCs) with low micromolar potency. The most effective complex, 1, elicits its cytotoxic effect by elevating the intracellular reactive oxygen species (ROS) levels and inhibiting cyclooxygenase-2 (COX-2) expression.
Funding
K. S. is supported by a Leverhulme Early Career Fellowship (ECF-2014-178). K. L. and A. E. are supported by a King's College London GTS-PhD Studentship and Faculty Graduate School International Studentship, respectively. C. L. thanks the National Natural Science Foundation of China (Grant No. 21401078) for financial support. We are grateful to Prof. Robert Weinberg (Whitehead Institute, MIT) for providing the cell lines used in this study.
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Citation
Dalton Transactions, 2017, 46 (38), pp. 12785-12789Author affiliation
/Organisation/COLLEGE OF SCIENCE AND ENGINEERING/Department of ChemistryVersion
- AM (Accepted Manuscript)
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Dalton TransactionsPublisher
Royal Society of Chemistryeissn
1477-9234Acceptance date
2017-09-03Copyright date
2017Available date
2019-06-14Publisher DOI
Publisher version
https://pubs.rsc.org/en/content/articlelanding/2017/DT/C7DT02789C#!divAbstractLanguage
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