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A spatial joint analysis of metal constituents of ambient particulate matter and mortality in England.

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journal contribution
posted on 2021-02-10, 12:07 authored by Aurore Lavigne, Anna Freni-Sterrantino, Daniela Fecht, Silvia Liverani, Marta Blangiardo, Kees de Hoogh, John Molitor, Anna L Hansell
Few studies have investigated associations between metal components of particulate matter on mortality due to well-known issues of multicollinearity. Here, we analyze these exposures jointly to evaluate their associations with mortality on small area data. We fit a Bayesian profile regression (BPR) to account for the multicollinearity in the elemental components (iron, copper, and zinc) of PM10 and PM2.5. The models are developed in relation to mortality from cardiovascular and respiratory disease and lung cancer incidence in 2008-2011 at a small area level, for a population of 13.6 million in the London-Oxford area of England. From the BPR, we identified higher risks in the PM10 fraction cluster likely to represent the study area, excluding London, for cardiovascular mortality relative risk (RR) 1.07 (95% credible interval [CI] 1.02, 1.12) and for respiratory mortality RR 1.06 (95%CI 0.99, 1.31), compared with the study mean. For PM2.5 fraction, higher risks were seen for cardiovascular mortality RR 1.55 (CI 95% 1.38, 1.71) and respiratory mortality RR 1.51 (CI 95% 1.33, 1.72), likely to represent the "highways" cluster. We did not find relevant associations for lung cancer incidence. Our analysis showed small but not fully consistent adverse associations between health outcomes and particulate metal exposures. The BPR approach identified subpopulations with unique exposure profiles and provided information about the geographical location of these to help interpret findings.

History

Citation

Environmental Epidemiology: August 2020 - Volume 4 - Issue 4 - p e098 doi: 10.1097/EE9.0000000000000098

Author affiliation

Department of Health Sciences, University of Leicester

Version

  • VoR (Version of Record)

Published in

Environmental epidemiology (Philadelphia, Pa.)

Volume

4

Issue

4

Pagination

e098

Publisher

Ovid Technologies (Wolters Kluwer Health)

issn

2474-7882

eissn

2474-7882

Acceptance date

2020-04-24

Copyright date

2020

Available date

2020-07-16

Spatial coverage

United States

Language

eng

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