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A systematic approach to diverse, lead-like scaffolds from α,α-disubstituted amino acids
journal contributionposted on 2019-02-22, 11:59 authored by DJ Foley, RG Doveston, I Churcher, A Nelson, SP Marsden
A powerful strategy for the efficient lead-oriented synthesis of novel molecular scaffolds is demonstrated. Twenty two scaffolds were prepared from just four α-amino acid-derived building blocks and a toolkit of six connective reactions. Importantly, each individual scaffold has the ability to specifically target lead-like chemical space.
We thank EPSRC (EP/J00894X) and GSK for funding.
CitationChem Commun (Camb), 2015, 51 (56), pp. 11174-11177
Author affiliation/Organisation/COLLEGE OF SCIENCE AND ENGINEERING/Department of Chemistry
- VoR (Version of Record)