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A systematic approach to diverse, lead-like scaffolds from α,α-disubstituted amino acids

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journal contribution
posted on 2019-02-22, 11:59 authored by DJ Foley, RG Doveston, I Churcher, A Nelson, SP Marsden
A powerful strategy for the efficient lead-oriented synthesis of novel molecular scaffolds is demonstrated. Twenty two scaffolds were prepared from just four α-amino acid-derived building blocks and a toolkit of six connective reactions. Importantly, each individual scaffold has the ability to specifically target lead-like chemical space.

Funding

We thank EPSRC (EP/J00894X) and GSK for funding.

History

Citation

Chem Commun (Camb), 2015, 51 (56), pp. 11174-11177

Author affiliation

/Organisation/COLLEGE OF SCIENCE AND ENGINEERING/Department of Chemistry

Version

  • VoR (Version of Record)

Published in

Chem Commun (Camb)

Publisher

Royal Society of Chemistry

eissn

1364-548X

Acceptance date

2015-05-11

Copyright date

2015

Available date

2019-02-22

Publisher version

https://pubs.rsc.org/en/Content/ArticleLanding/2015/CC/C5CC03002A#!divAbstract

Language

en

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