posted on 2019-02-22, 11:59authored byDJ Foley, RG Doveston, I Churcher, A Nelson, SP Marsden
A powerful strategy for the efficient lead-oriented synthesis of novel molecular scaffolds is demonstrated. Twenty two scaffolds were prepared from just four α-amino acid-derived building blocks and a toolkit of six connective reactions. Importantly, each individual scaffold has the ability to specifically target lead-like chemical space.
Funding
We thank EPSRC (EP/J00894X) and GSK for funding.
History
Citation
Chem Commun (Camb), 2015, 51 (56), pp. 11174-11177
Author affiliation
/Organisation/COLLEGE OF SCIENCE AND ENGINEERING/Department of Chemistry