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Abnormal corticosteroid signalling in airway smooth muscle: mechanisms and perspectives for the treatment of severe asthma.

journal contribution
posted on 2015-12-11, 16:16 authored by L. Chachi, A. Gavrila, O. Tliba, Yassine Amrani
Growing in vivo evidence supports the concept that airway smooth muscle produces various immunomodulatory factors that could contribute to asthma pathogenesis via the regulation of airway inflammation, airway narrowing and remodelling. Targeting ASM using bronchial thermoplasty has provided undeniable clinical benefits for patients with uncontrolled severe asthma who are refractory to glucocorticoid therapy. The present review will explain why the failure of glucocorticoids to adequately manage patients with severe asthma could derive from their inability to affect the immunomodulatory potential of ASM. We will support the view that ASM sensitivity to glucocorticoid therapy can be blunted in severe asthma and will describe some of the factors and mechanisms that could be responsible for glucocorticoid insensitivity.

History

Citation

Clinical and Experimental Allergy, 2015, 45 (11), pp. 1637-1646

Author affiliation

/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGY/School of Medicine/Department of Infection, Immunity and Inflammation

Version

  • AM (Accepted Manuscript)

Published in

Clinical and Experimental Allergy

Publisher

Wiley

issn

0954-7894

eissn

1365-2222

Acceptance date

2015-05-27

Copyright date

2015

Available date

2016-10-15

Publisher version

http://onlinelibrary.wiley.com/doi/10.1111/cea.12577/abstract

Language

en

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