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Advanced-stage cervix cancer: rapid tumour growth rather than late diagnosis..pdf (46.36 kB)

Advanced-stage cervix cancer: rapid tumour growth rather than late diagnosis

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journal contribution
posted on 2016-04-06, 08:49 authored by Raymond Symonds, B. Bolger, D. Hole, J. H. Mao, T. Cooke
Either diagnostic delay or tumour biology are possible factors governing the degree of spread at diagnosis of cervical cancer. To try to identify the most important parameter contributing to advanced stage, the duration of symptoms were recorded from patients scheduled for radiotherapy (n = 141) or radical hysterectomy (n = 36). In 146 cases tumour proliferation rates were evaluated following in vivo labelling with the DNA precursor BrdUrd. For symptomatic patients there was no association between duration of symptoms and stage at presentation. There was a significant trend for patients with increasing tumour stage to have more rapidly proliferating tumours with higher mean labelling index (LI) measurements (P = 0.001) and a shorter mean potential doubling time (Tpot) (P = 0.023). Socio economic deprivation may be associated with shorter Tpot values. The conclusion from this data is that stage at diagnosis is more dependent on the biological behaviour of the tumour, as expressed by proliferation rates, than delay in presentation.

History

Citation

Birtish Journal of Cancer, 2000, 83 (5), pp. 566-568

Author affiliation

/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGY/MBSP Non-Medical Departments/Department of Genetics

Version

  • VoR (Version of Record)

Published in

Birtish Journal of Cancer

Publisher

Cancer Research UK, Nature Publishing Group

issn

0007-0920

eissn

1532-1827

Acceptance date

2000-05-17

Copyright date

2000

Available date

2016-04-06

Publisher version

http://www.nature.com/bjc/journal/v83/n5/full/6691336a.html

Language

en

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