Amyloidosis in the Era of Mass Spectrometry-Based Proteomics

I read the paper by Kotecha et al. with great interest. Certainly, the authors conducted a very valuable and exciting study for which 286 patients were recruited, including 100 with systemic light-chain amyloidosis and 163 with cardiac transthyretin amyloidosis. The findings in this study by histology and cardiovascular magnetic resonance T2 mapping suggest that myocardial edema is a mechanism additional to amyloid infiltration in contributing to prognosis in amyloidosis