University of Leicester
Browse
Khubrani_Revised_121218_ForLRA.pdf (1.56 MB)

Analysis of 21 autosomal STRs in Saudi Arabia reveals population structure and the influence of consanguinity

Download (1.56 MB)
journal contribution
posted on 2019-03-07, 10:20 authored by YM Khubrani, JH Wetton, MA Jobling
Variation in the 21 autosomal STRs detected by the GlobalFiler multiplex was investigated in a sample of 523 indigenous male Arabs from five geographic regions of Saudi Arabia. Although allele frequencies for the entire dataset were found to be broadly similar to those determined in previous studies of Saudi citizens, significant differences were found among regions. Heterozygote deficiency was observed at nearly all loci in all regions, probably as a consequence of high levels of consanguineous marriage; in the case of D2S1338, which showed the largest deviation from Hardy-Weinberg equilibrium, the presence of a null allele also played a part. Genetic distances were greatest between the Northern and Southern regions, whilst the West, Central and East appeared most similar to each other, and to previously published surveys. This contrasts with previously described variation among paternal lineages in the same sample-set: Y-chromosome variation was limited within the North/Central/South core compared with the more diverse East and West. Differences between autosomal and Y-chromosomal patterns may reflect genetic drift on the Y chromosome, exacerbated by prevalent patrilineal descent groups in different regions.

Funding

YMK was supported by the Saudi Arabian Ministry of Interior, and by a PhD studentship from the Saudi Arabian Cultural Bureau, London.

History

Citation

Forensic Science International: Genetics, 2019, 39, pp. 97-102

Author affiliation

/Organisation/COLLEGE OF LIFE SCIENCES/Biological Sciences/Genetics and Genome Biology

Version

  • AM (Accepted Manuscript)

Published in

Forensic Science International: Genetics

Publisher

Elsevier for International Society for Forensic Genetics

issn

1872-4973

eissn

1878-0326

Acceptance date

2018-12-18

Copyright date

2018

Publisher version

https://www.sciencedirect.com/science/article/pii/S1872497318305404?via=ihub

Notes

The file associated with this record is under embargo until 12 months after publication, in accordance with the publisher's self-archiving policy. The full text may be available through the publisher links provided above.

Language

en

Usage metrics

    University of Leicester Publications

    Categories

    Keywords

    Exports

    RefWorks
    BibTeX
    Ref. manager
    Endnote
    DataCite
    NLM
    DC