Anti-breast cancer stem cell activity of titanocene complexes of non-steroidal anti-inflammatory drugs.
journal contribution
posted on 2025-10-31, 10:17 authored by Olympia Mouriki, Ginevra Passeri, Karampal Singh, Sarah D Lamorte, Kuldip Singh, Kogularamanan SuntharalingamKogularamanan Suntharalingam, Sandy KilpatrickSandy KilpatrickTitanocene(IV)-NSAID complexes Cp<sub>2</sub>Ti(mefenamate)<sub>2</sub> (4) and Cp<sub>2</sub>Ti(flufenamate)<sub>2</sub> (5) show enhanced redox stability and potent cytotoxicity against breast cancer stem cells (CSCs), with 5 rivaling salinomycin and cisplatin. Complex 5 induces DNA damage and apoptosis, and its nanoparticle encapsulation improves biocompatibility. This is the first report targeting breast CSCs with titanocene-based metallodrugs.<p></p>
History
Author affiliation
University of Leicester College of Science & Engineering ChemistryVersion
- VoR (Version of Record)
