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Antimicrobial peptides play a functional role in bumblebee anti-trypanosome defense

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journal contribution
posted on 2013-09-26, 13:55 authored by Soni Deshwal, Eamonn B. Mallon
Bumblebees, amongst the most important of pollinators, are under enormous population pressures. One of these is disease. The bumblebee and its gut trypanosome Crithidia bombi are one of the fundamental models of ecological immunology. Although there is previous evidence of increased immune gene expression upon Crithidia infection, recent work has focussed on the bumblebee’s gut microbiota. Here, by knocking down gene expression using RNAi, we show for the first time that antimicrobial peptides (AMPs) have a functional role in anti-Crithidia defense.

History

Citation

Developmental and Comparative Immunology, in press

Author affiliation

/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGY/School of Biological Sciences/Department of Biology

Version

  • AM (Accepted Manuscript)

Published in

Developmental and Comparative Immunology

Publisher

Elsevier for the International Society of Developmental and Comparative Immunology

issn

0145-305X

eissn

1879-0089

Copyright date

2013

Available date

2013-09-26

Publisher version

http://www.sciencedirect.com/science/article/pii/S0145305X13002565

Notes

NOTICE: this is the author’s version of a work that was accepted for publication in Developmental and Comparative Immunology. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Developmental and Comparative Immunology, [in press] DOI#10.1016/j.dci.2013.09.004.

Language

en

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