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Application of mesoporous silica nanoparticles as drug delivery carriers for chemotherapeutic agents

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journal contribution
posted on 2020-09-17, 13:30 authored by Y Alyassin, EG Sayed, P Mehta, K Ruparelia, MS Arshad, M Rasekh, Jennifer Shepherd, I Kucuk, PB Wilson, N Singh, MW Chang, DG Fatouros, Z Ahmad
Recently, remarkable efforts have focused on research towards enhancing and delivering efficacious and advanced therapeutic agents. Even though this involves significant challenges, innovative techniques and materials have been explored to overcome these. The advantageous properties of mesoporous silica nanoparticles (MSNs), such as unique morphologies and geometries, makes then favorable for use for various drug delivery targeting purposes, particularly in cancer therapy. As we discuss here, MSNs have been utilized over the past few decades to improve the efficiency of anticancer drugs by enhancing their solubility to render them suitable for application, reducing adverse effects, and improving their anticancer cytotoxic efficiency.

History

Citation

Drug Discovery Today, Volume 25, Issue 8, August 2020, Pages 1513-1520

Author affiliation

School of Engineering

Version

  • AM (Accepted Manuscript)

Published in

Drug Discovery Today

Volume

25

Issue

8

Pagination

1513 - 1520

Publisher

Elsevier

issn

1359-6446

eissn

1878-5832

Acceptance date

2020-06-08

Copyright date

2020

Available date

2020-06-16

Spatial coverage

England

Language

English

Publisher version

https://www.sciencedirect.com/science/article/pii/S1359644620302312?via=ihub#!

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