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Assessing and Modulating Kynurenine Pathway Dynamics in Huntington's Disease: Focus on Kynurenine 3-Monooxygenase.

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posted on 2020-04-24, 13:52 authored by Korrapati V. Sathyasaikumar, Carlo Breda, Robert Schwarcz, Flaviano Giorgini
The link between disturbances in kynurenine pathway (KP) metabolism and Huntington's disease (HD) pathogenesis has been explored for a number of years. Several novel genetic and pharmacological tools have recently been developed to modulate key regulatory steps in the KP such as the reaction catalyzed by the enzyme kynurenine 3-monooxygenase (KMO). This insight has offered new options for exploring the mechanistic link between this metabolic pathway and HD, and provided novel opportunities for the development of candidate drug-like compounds. Here, we present an overview of the field, focusing on some novel approaches for interrogating the pathway experimentally.

History

Citation

Methods Mol Biol, 2018, 1780, pp. 397-413

Author affiliation

Department of Genetics and Genome Biology

Version

  • AM (Accepted Manuscript)

Published in

Methods Mol Biol

Pagination

397-413

Publisher

Humana Press

eissn

1940-6029

Available date

2018-06-01

Publisher version

https://link.springer.com/protocol/10.1007/978-1-4939-7825-0_18

Language

eng

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