Kumar et al., final author submitted.pdf (476.16 kB)
Assessing and Modulating Kynurenine Pathway Dynamics in Huntington's Disease: Focus on Kynurenine 3-Monooxygenase.
journal contributionposted on 2020-04-24, 13:52 authored by Korrapati V. Sathyasaikumar, Carlo Breda, Robert Schwarcz, Flaviano Giorgini
The link between disturbances in kynurenine pathway (KP) metabolism and Huntington's disease (HD) pathogenesis has been explored for a number of years. Several novel genetic and pharmacological tools have recently been developed to modulate key regulatory steps in the KP such as the reaction catalyzed by the enzyme kynurenine 3-monooxygenase (KMO). This insight has offered new options for exploring the mechanistic link between this metabolic pathway and HD, and provided novel opportunities for the development of candidate drug-like compounds. Here, we present an overview of the field, focusing on some novel approaches for interrogating the pathway experimentally.
CitationMethods Mol Biol, 2018, 1780, pp. 397-413
Author affiliationDepartment of Genetics and Genome Biology
- AM (Accepted Manuscript)