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Association of ethnicity and socioeconomic status with health outcomes in women with gestational diabetes: Clinical practice research datalink cohort study

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posted on 2024-05-09, 10:01 authored by Elpida Vounzoulaki, Joanne K Miksza, Francesco Zaccardi, Bee K Tan, Melanie J Davies, Kamlesh Khunti, Clare L Gillies

Aims: To investigate in women with prior gestational diabetes mellitus (GDM), differences by ethnicity and socioeconomic status in the incidence of recurrent GDM, type 2 diabetes (T2D), hypertension, and depression. Methods: This was a retrospective cohort study including 10,868 women diagnosed with GDM in the Clinical Practice Research Datalink (CPRD GOLD) between January 01, 2000 and November 05, 2018. Linked data were obtained for Hospital Episode Statistics and the Index of Multiple Deprivation. We estimated incidence rates and hazard ratios, by ethnicity and socioeconomic status. Results: During a follow-up of 58,479 person years (mean (SD): 5.38 (3.67) years), the crude incidence was 9.67 (95 % confidence interval: 9.30–10.00) per 100 person years for recurrent GDM, 3.86 (3.70–4.02) for depression, 2.15 (2.03–2.27) for T2D and 0.89 (0.81–0.97) for hypertension. South Asian ethnicity was associated with an increased risk of T2D compared to White (adjusted hazard ratio: 1.65; 1.34–2.05) and Black ethnicity was associated with a greater risk of hypertension (2.93; 1.93–4.46). Black and South Asian ethnicity were associated with a reduced risk of depression compared to White: 0.23 (0.13–0.39) and 0.37 (0.29–0.46), respectively. Incidence rates were higher for all conditions with increasing deprivation level. Conclusions: The risk of health complications in women with a prior history of GDM differs by ethnicity and socio- economic status, suggesting the opportunity for targeted assessment in the years following pregnancy. These findings may inform future guidelines on screening for health outcomes in women with GDM

Funding

This report is the independent research of EV, supported by the National Institute for Health Research (NIHR) Applied Research Collaboration-East Midlands as part of a PhD project. This research is also supported by the NIHR Leicester Biomedical Research Centre.

History

Author affiliation

College of Life Sciences/Population Health Sciences

Published in

Diabetes & Metabolic Syndrome: Clinical Research & Reviews

Volume

18

Issue

4

Pagination

103010

Publisher

Elsevier BV

issn

1871-4021

eissn

1878-0334

Copyright date

2024

Available date

2024-05-09

Spatial coverage

Netherlands

Language

en

Deposited by

Dr Clare Gillies

Deposit date

2024-05-03

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