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Auditory Efferent System Modulates Mosquito Hearing

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posted on 2019-04-29, 09:19 authored by M Andrés, M Seifert, C Spalthoff, B Warren, L Weiss, D Giraldo, M Winkler, S Pauls, MC Göpfert
The performance of vertebrate ears is controlled by auditory efferents that originate in the brain and innervate the ear, synapsing onto hair cell somata and auditory afferent fibers [1, 2, 3]. Efferent activity can provide protection from noise and facilitate the detection and discrimination of sound by modulating mechanical amplification by hair cells and transmitter release as well as auditory afferent action potential firing [1, 2, 3]. Insect auditory organs are thought to lack efferent control [4, 5, 6, 7], but when we inspected mosquito ears, we obtained evidence for its existence. Antibodies against synaptic proteins recognized rows of bouton-like puncta running along the dendrites and axons of mosquito auditory sensory neurons. Electron microscopy identified synaptic and non-synaptic sites of vesicle release, and some of the innervating fibers co-labeled with somata in the CNS. Octopamine, GABA, and serotonin were identified as efferent neurotransmitters or neuromodulators that affect auditory frequency tuning, mechanical amplification, and sound-evoked potentials. Mosquito brains thus modulate mosquito ears, extending the use of auditory efferent systems from vertebrates to invertebrates and adding new levels of complexity to mosquito sound detection and communication.

Funding

We thank Jörg Egger and Melanie Nolden, Bayer CropBioscience, for providing the experimental animals, the Develpmental Hybridoma Bank for antibodies, Maike Kittelmann and Carolin Wichmann for help with electron microscopy, and Bart Geurten, Heribert Gras, Ralf Heinrich, and Andreas Stumpner for discussions. This work was supported by the International Max Planck Research School Neurosciences, Göttingen (to L.W.) and the German Science Foundation (DFG, GO 1092/4-1, SPP 1608, GO 1092/2-3, SFB 889 A1, and INST 186/1081-1) to M.C.G

History

Citation

Current Biology, 2016, 26 (15), pp. 2028-2036

Author affiliation

/Organisation/COLLEGE OF LIFE SCIENCES/Biological Sciences/Neuroscience, Psychology and Behaviour

Version

  • AM (Accepted Manuscript)

Published in

Current Biology

Publisher

Elsevier (Cell Press)

issn

0960-9822

Acceptance date

2016-05-31

Copyright date

2016

Available date

2019-04-29

Publisher version

https://www.sciencedirect.com/science/article/pii/S096098221630611X?via=ihub

Notes

Supplemental Information includes Supplemental Experimental Procedures and three figures and can be found with this article online at http://dx.doi.org/10.1016/j.cub.2016.05.077

Language

en

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