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Auditory robustness and resilience in the aging auditory system of the desert locust

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posted on 2024-01-31, 10:07 authored by TT Austin, CL Thomas, B Warren
After overexposure to loud music, we experience a decrease in our ability to hear (robustness), which usually recovers (resilience). Here, we exploited the amenable auditory system of the desert locust, Schistocerca gregaria, to measure how robustness and resilience depend on age. We found that gene expression changes are dominated by age as opposed to noise exposure. We measured sound-evoked nerve activity for young and aged locusts directly, after 24 hours and 48 hours after noise exposure. We found that both young and aged locusts recovered their auditory nerve function over 48 hours. We also measured the sound-evoked transduction current in individual auditory neurons, and although the transduction current magnitude recovered in the young locusts after noise exposure, it failed to recover in the aged locusts. A plastic mechanism compensates for the decreased transduction current in aged locusts. We suggest key genes upregulated in young noise-exposed locusts that mediate robustness to noise exposure and find potential candidates responsible for compensatory mechanisms in the auditory neurons of aged noise-exposed locusts.

Funding

Royal Society University Research Fellowship URF\R1\180022

Enhancement Award FR\ERE210220

History

Citation

Thomas T. Austin, Christian L. Thomas, Ben Warren, Auditory robustness and resilience in the aging auditory system of the desert locust, Neurobiology of Aging, Volume 133, 2024, Pages 39-50, ISSN 0197-4580, https://doi.org/10.1016/j.neurobiolaging.2023.09.009.

Author affiliation

Neurogenetics Group, College of Life Sciences, University of Leicester

Version

  • VoR (Version of Record)

Published in

Neurobiology of Aging

Volume

133

Pagination

39 - 50

Publisher

Elsevier BV

issn

0197-4580

eissn

1558-1497

Acceptance date

2023-09-19

Copyright date

2023

Available date

2024-01-31

Spatial coverage

United States

Language

eng

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