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Auditory robustness and resilience in the aging auditory system of the desert locust
journal contributionposted on 2024-01-31, 10:07 authored by TT Austin, CL Thomas, B Warren
After overexposure to loud music, we experience a decrease in our ability to hear (robustness), which usually recovers (resilience). Here, we exploited the amenable auditory system of the desert locust, Schistocerca gregaria, to measure how robustness and resilience depend on age. We found that gene expression changes are dominated by age as opposed to noise exposure. We measured sound-evoked nerve activity for young and aged locusts directly, after 24 hours and 48 hours after noise exposure. We found that both young and aged locusts recovered their auditory nerve function over 48 hours. We also measured the sound-evoked transduction current in individual auditory neurons, and although the transduction current magnitude recovered in the young locusts after noise exposure, it failed to recover in the aged locusts. A plastic mechanism compensates for the decreased transduction current in aged locusts. We suggest key genes upregulated in young noise-exposed locusts that mediate robustness to noise exposure and find potential candidates responsible for compensatory mechanisms in the auditory neurons of aged noise-exposed locusts.
Royal Society University Research Fellowship URF\R1\180022
Enhancement Award FR\ERE210220
CitationThomas T. Austin, Christian L. Thomas, Ben Warren, Auditory robustness and resilience in the aging auditory system of the desert locust, Neurobiology of Aging, Volume 133, 2024, Pages 39-50, ISSN 0197-4580, https://doi.org/10.1016/j.neurobiolaging.2023.09.009.
Author affiliationNeurogenetics Group, College of Life Sciences, University of Leicester
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