University of Leicester
Browse

File(s) under embargo

10

month(s)

7

day(s)

until file(s) become available

BCL2 inhibition: back to the future!

journal contribution
posted on 2024-05-07, 13:13 authored by Martin JS Dyer, Harriet S Walter

In this issue of Blood, Liu and colleagues report the preliminary characterization of a new BCL2-specific inhibitor (BCL2i), sonrotoclax, which not only binds with higher affinity to BCL2 than the first-in-class BCL2i venetoclax, but also induces apoptosis in models bearing venetoclax-induced BCL2 mutations.1 These important data suggest that sonrotoclax may find clinical applications in BCL2-dependent malignancies. [Opening paragraph]

History

Author affiliation

College of Life Sciences/Genetics & Genome Biology

Version

  • VoR (Version of Record)

Published in

Blood

Volume

143

Issue

18

Pagination

1787 - 1788

Publisher

American Society of Hematology

issn

0006-4971

eissn

1528-0020

Copyright date

2024

Available date

2025-05-02

Spatial coverage

United States

Language

en

Deposited by

Dr Harriet Walter

Deposit date

2024-05-05

Usage metrics

    University of Leicester Publications

    Categories

    No categories selected

    Exports

    RefWorks
    BibTeX
    Ref. manager
    Endnote
    DataCite
    NLM
    DC