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Cell-free DNA analysis in current cancer clinical trials: a review

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posted on 2024-01-25, 14:51 authored by M Cisneros-Villanueva, L Hidalgo-Pérez, M Rios-Romero, A Cedro-Tanda, CA Ruiz-Villavicencio, K Page, R Hastings, D Fernandez-Garcia, R Allsopp, MA Fonseca-Montaño, S Jimenez-Morales, V Padilla-Palma, JA Shaw, A Hidalgo-Miranda

Cell-free DNA (cfDNA) analysis represents a promising method for the diagnosis, treatment selection and clinical follow-up of cancer patients. Although its general methodological feasibility and usefulness has been demonstrated, several issues related to standardisation and technical validation must be addressed for its routine clinical application in cancer. In this regard, most cfDNA clinical applications are still limited to clinical trials, proving its value in several settings. In this paper, we review the current clinical trials involving cfDNA/ctDNA analysis and highlight those where it has been useful for patient stratification, treatment follow-up or development of novel approaches for early diagnosis. Our query included clinical trials, including the terms ‘cfDNA’, ‘ctDNA’, ‘liquid biopsy’ AND ‘cancer OR neoplasm’ in the FDA and EMA public databases. We identified 1370 clinical trials (FDA = 1129, EMA = 241) involving liquid-biopsy analysis in cancer. These clinical trials show promising results for the early detection of cancer and confirm cfDNA as a tool for real-time monitoring of acquired therapy resistance, accurate disease-progression surveillance and improvement of treatment, situations that result in a better quality of life and extended overall survival for cancer patients.

History

Author affiliation

Leicester Cancer Research Centre, Department of Genetics and Genome Biology, University of Leicester

Version

  • VoR (Version of Record)

Published in

British Journal of Cancer

Volume

126

Issue

3

Pagination

391 - 400

Publisher

Springer Science and Business Media LLC

issn

0007-0920

eissn

1532-1827

Copyright date

2022

Available date

2024-01-25

Spatial coverage

England

Language

eng

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