Aitta-aho et al., 2016.pdf (1.18 MB)
Cellular activation of hypothalamic hypocretin/orexin neurons facilitates short-term spatial memory in mice.
journal contributionposted on 2017-05-08, 13:20 authored by Teemu Aitta-Aho, Elpiniki Pappa, Denis Burdakov, John Apergis-Schoute
The hypothalamic hypocretin/orexin (HO) system holds a central role in the regulation of several physiological functions critical for food-seeking behavior including mnemonic processes for effective foraging behavior. It is unclear however whether physiological increases in HO neuronal activity can support such processes. Using a designer rM3Ds receptor activation approach increasing HO neuronal activity resulted in improved short-term memory for novel locations. When tested on a non-spatial novelty object recognition task no significant difference was detected between groups indicating that hypothalamic HO neuronal activation can selectively facilitate short-term spatial memory for potentially supporting memory for locations during active exploration.
This work was supported by the Royal Society – UK (JAS), Sigrid Juselius Foundation (TA) and Erasmus Scholarship (EP).Open Access funded by Wellcome Trust.
CitationNeurobiology of Learning and Memory, 2016, 136, pp. 183-188
Author affiliation/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGY/MBSP Non-Medical Departments/Neuroscience, Psychology and Behaviour
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