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Cellular activation of hypothalamic hypocretin/orexin neurons facilitates short-term spatial memory in mice.

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posted on 2017-05-08, 13:20 authored by Teemu Aitta-Aho, Elpiniki Pappa, Denis Burdakov, John Apergis-Schoute
The hypothalamic hypocretin/orexin (HO) system holds a central role in the regulation of several physiological functions critical for food-seeking behavior including mnemonic processes for effective foraging behavior. It is unclear however whether physiological increases in HO neuronal activity can support such processes. Using a designer rM3Ds receptor activation approach increasing HO neuronal activity resulted in improved short-term memory for novel locations. When tested on a non-spatial novelty object recognition task no significant difference was detected between groups indicating that hypothalamic HO neuronal activation can selectively facilitate short-term spatial memory for potentially supporting memory for locations during active exploration.

Funding

This work was supported by the Royal Society – UK (JAS), Sigrid Juselius Foundation (TA) and Erasmus Scholarship (EP).Open Access funded by Wellcome Trust.

History

Citation

Neurobiology of Learning and Memory, 2016, 136, pp. 183-188

Author affiliation

/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGY/MBSP Non-Medical Departments/Neuroscience, Psychology and Behaviour

Version

  • VoR (Version of Record)

Published in

Neurobiology of Learning and Memory

Publisher

Elsevier

issn

1074-7427

eissn

1095-9564

Acceptance date

2016-10-06

Copyright date

2016

Available date

2017-05-08

Publisher version

http://www.sciencedirect.com/science/article/pii/S1074742716302507

Language

en

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