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Malaikah et al 2023 - APNM_uploaded.pdf (619.56 kB)

Circulating leukocyte cell-derived chemotaxin 2 and fibroblast growth factor 21 are negatively associated with cardiorespiratory fitness in healthy volunteers.

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posted on 2023-05-22, 10:05 authored by Sundus Malaikah, Scott A Willis, Joseph Henson, Jack A Sargeant, Thomas Yates, Alice E Thackray, Fernanda R Goltz, Matthew J Roberts, Danielle Bernard-Deshong, Guruprasad P Aithal, David J Stensel, James A King
Leukocyte cell-derived chemotaxin-2 (LECT2) and fibroblast growth factor 21 (FGF21) are hepatokines that are regulated by energy balance and mediate insulin sensitivity and glycaemic control. This cross-sectional study examined the independent associations of cardiorespiratory fitness (CRF), moderate-to-vigorous intensity physical activity (MVPA), and sedentary time with circulating LECT2 and FGF21. Data were combined from two previous experimental studies in healthy volunteers (n = 141, male = 60%, mean ± SD age = 37 ± 19 years, body mass index (BMI) = 26.1 ± 6.3 kg·m-2). Sedentary time and MVPA were measured via an ActiGraph GT3X + accelerometer, while magnetic resonance imaging quantified liver fat. CRF was assessed using incremental treadmill tests. Generalized-linear models examined the association of CRF, sedentary time, and MVPA with LECT2 and FGF21 while controlling for key demographic and anthropometric variables. Interaction terms explored the moderating influence of age, sex, BMI, and CRF. In the fully adjusted models, each SD increase in CRF was independently associated with a 24% (95% CI: -37% to -9%, P = 0.003) lower plasma LECT2 concentration and 53% lower FGF21 concentration (95% CI: -73% to -22%, P = 0.004). Each SD increase in MVPA was independently associated with 55% higher FGF21 (95% CI: 12% to 114%, P = 0.006), and this relationship was stronger in those with lower BMI and higher levels of CRF. These findings demonstrate that CRF and wider activity behaviours may independently modulate the circulating concentrations of hepatokines and thereby influence inter-organ cross-talk.

History

Author affiliation

Diabetes Research Centre, University of Leicester

Version

  • AM (Accepted Manuscript)

Published in

Applied Physiology, Nutrition, and Metabolism

Publisher

Canadian Science Publishing

issn

1715-5312

eissn

1715-5320

Copyright date

2023

Available date

2023-05-22

Spatial coverage

Canada

Language

eng

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