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Classification of Alzheimer’s Disease Based on Weakly Supervised Learning and Attention Mechanism

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posted on 2023-07-07, 09:26 authored by X Wu, S Gao, J Sun, Y Zhang, S Wang
The brain lesions images of Alzheimer’s disease (AD) patients are slightly different from the Magnetic Resonance Imaging of normal people, and the classification effect of general image recognition technology is not ideal. Alzheimer’s datasets are small, making it difficult to train large-scale neural networks. In this paper, we propose a network model (WS-AMN) that fuses weak supervision and an attention mechanism. The weakly supervised data augmentation network is used as the basic model, the attention map generated by weakly supervised learning is used to guide the data augmentation, and an attention module with channel domain and spatial domain is embedded in the residual network to focus on the distinctive channels and spaces of images respectively. The location information enhances the corresponding features of related features and suppresses the influence of irrelevant features.The results show that the F1-score is 99.63%, the accuracy is 99.61%. Our model provides a high-performance solution for accurate classification of AD.

Funding

This research wsa funded by: National Natural Science Foundation of China (62276092); Key Science and Technology Program of Henan Province, CN (212102310084); Key Scientific Research Projects of Colleges and Universities in Henan Province, CN (22A520027); British Heart Foundation Accelerator Award, UK (AA/18/3/34220); Royal Society International Exchanges Cost Share Award, UK (RP202G0230); Hope Foundation for Cancer Research, UK (RM60G0680); Medical Research Council Confidence in Concept Award, UK (MC_PC_17171); Sino-UK Industrial Fund, UK (RP202G0289); Global Challenges Research Fund (GCRF), UK (P202PF11); LIAS Pioneering Partnerships award, UK (P202ED10); Data Science Enhancement Fund, UK (P202RE237).

History

Citation

Wu, X.; Gao, S.; Sun, J.; Zhang, Y.; Wang, S. Classification of Alzheimer’s Disease Based on Weakly Supervised Learning and Attention Mechanism. Brain Sci. 2022, 12, 1601. https://doi.org/10.3390/brainsci12121601

Author affiliation

School of Computing and Mathematical Sciences

Version

  • VoR (Version of Record)

Published in

Brain Sciences

Volume

12

Issue

12

Pagination

1601

Publisher

MDPI

issn

2076-3425

eissn

2076-3425

Acceptance date

2022-11-19

Copyright date

2022

Available date

2022-11-23

Spatial coverage

Switzerland

Language

eng

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