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Clinical update on cancer: molecular oncology of head and neck cancer

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journal contribution
posted on 2016-02-23, 11:39 authored by Y. Suh, I. Amelio, T. Guerrero Urbano, M. Tavassoli
Head and neck cancers encompass a heterogeneous group of tumours that, in general, are biologically aggressive in nature. These cancers remain difficult to treat and treatment can cause severe, long-term side effects. For patients who are not cured by surgery and/or (chemo)radiotherapy, there are few effective treatment options. Targeted therapies and predictive biomarkers are urgently needed in order to improve the management and minimise the treatment toxicity, and to allow selection of patients who are likely to benefit from both nonselective and targeted therapies. This clinical update aims to provide an insight into the current understanding of the molecular pathogenesis of the disease, and explores the novel therapies under development and in clinical trials.

Funding

We thank King’s Health Partners, King’s College London and the Rosetrees Trust for supporting Dr. Yae-eun Suh.

History

Citation

Cell Death and Disease (2014) 5, e1018

Version

  • VoR (Version of Record)

Published in

Cell Death and Disease (2014) 5

Publisher

Nature Publishing Group for Associazione Differenziamento e Morte Cellulare

issn

2041-4889

eissn

2041-4889

Acceptance date

2013-12-05

Available date

2016-02-23

Publisher version

http://www.nature.com/cddis/journal/v5/n1/full/cddis2013548a.html

Language

en

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