Combined use of trimethylamine N-oxide with BNP for risk stratification in heart failure with preserved ejection fraction: findings from the DIAMONDHFpEF study
journal contribution
posted on 2020-11-09, 10:12 authored by A Salzano, M Israr, Y Yazaki, L Heaney, P Kanagala, A Singh, J Arnold, G Gulsin, I Squire, G McCann, L Ng, T SuzukiCirculating levels of Trimethylamine N-oxide (TMAO), a gut microbiome-mediated metabolite
related to Western diet1, 2
, have been shown to be associated with risk stratification and outcome in
patients with heart failure (HF) with reduced ejection fraction (HFrEF)
3-6
. The aim of the present study
was to assess the associations between TMAO with outcomes in patients with HF with preserved
ejection fraction (HFpEF).
Funding
This work was supported by the Practical Research Project for Life-Style related Diseases including Cardiovascular Diseases and Diabetes Mellitus from Japan Agency for Medical Research and Development (AMED), the Japan Heart Foundation, the University of Tokyo, the John and Lucille van Geest Foundation, and the National Institute for Health Research (NIHR) Leicester Biomedical Research Centre. Dr Salzano receives research grant support from Cardiopath, UniNA and Compagnia di San Paolo in the frame of Programme STAR. Prof McCann was supported by an NIHR Career Development fellowship 2014-07-045 and holds an NIHR Research Professorship 2017-08-ST2-007. Dr Kanagala, Dr Singh, and Dr Arnold were supported by the NIHR Leicester Biomedical Research Centre.
History
Citation
European Journal of Preventive Cardiology, https://doi.org/10.1177/2047487319870355Author affiliation
/Organisation/COLLEGE OF LIFE SCIENCES/School of Medicine/Department of Cardiovascular SciencesVersion
- AM (Accepted Manuscript)
Published in
European Journal of Preventive CardiologyPublisher
SAGE Publications (UK and US), European Society of Cardiology, European Association for Cardiovascular Prevention and Rehabilitationeissn
2047-4881Acceptance date
2019-07-29Copyright date
2019Available date
2019-08-14Publisher DOI
Notes
The file associated with this record is under embargo until publication, in accordance with the publisher's self-archiving policy. The full text may be available through the publisher links provided above.Language
enAdministrator link
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