Common breast cancer susceptibility alleles are associated with tumour subtypes in BRCA1 and BRCA2 mutation carriers: results from the Consortium of Investigators of Modifiers of BRCA1/2.

Mulligan, A. M.; Couch, F. J.; Barrowdale, D.; Domchek, S. M.; Eccles, D.; Nevanlinna, H.; Ramus, S. J.; Robson, M.; Sherman, M.; Spurdle, A. B.; Wappenschmidt, B.; Hansen, T. V.; Karlsson, P.; Ding, Y. C.; Neuhausen, S. L.; Network, Ontario Cancer Genetics; Beattie, M.; Pharoah, P. D.; Ejlertsen, B.; Moysich, K. B.; Southey, M. C.; Niederacher, D.; Andrulis, I. L.; Schoenbuchner, I.; CIMBA,; Mazoyer, S.; Osorio, A.; Coupier, I.; Muñoz-Repeto, I.; Durán, M.; Godino, J.; Pertesi, M.; Sutter, C.; Benítez, J.; Peterlongo, P.; Fiebig, B.; Manoukian, S.; Peissel, B.; Léoné, M.; Zaffaroni, D.; Cattaneo, E.; Lebrun, M.; Bonanni, B.; Deissler, H.; Viel, A.; Pasini, B.; Papi, L.; Heinritz, W.; Ottini, L.; Savarese, A.; Bernard, L.; Boutry-Kryza, N.; Radice, P.; Hamann, U.; Gadzicki, D.; Verheus, M.; Kientz, C.; Meijers-Heijboer, H. E.; Wijnen, J.; Schäfer, D.; Gómez García, E. B.; Nelen, M. R.; Kets, C. M.; Seynaeve, C.; Hardouin, A.; Isaacs, C.; Tilanus-Linthorst, M. M.; van der Luijt, R. B.; van Os, T.; Rookus, M.; Longy, M.; Gevensleben, H.; Frost, D.; Jones, J. L.; Evans, D. G.; Lalloo, F.; Kast, K.; Eeles, R.; Berthet, P.; Izatt, L.; Adlard, J.; Davidson, R.; Cook, J.; Caux-Moncoutier, V.; Donaldson, A.; Sevenet, N.; Dorkins, H.; Preisler-Adams, S.; Gregory, H.; Eason, J.; Houghton, C.; Muller, D.; Barwell, J.; Side, L. E.; McCann, E.; Fassy-Colcombet, M.; Murray, A.; Peock, S.; Mortemousque, I.; Godwin, A. K.; Stoppa-Lyonnet, D.; Schmutzler, R. K.; Rhiem, K.; Engel, C.; Fricker, J. P.; Meindl, A.; Ruehl, I.; Caldes, T.; Arnold, N.; Varon-Mateeva, R.; Cornelis, F.; Nathanson, K. L.; Pujol, P.; Hopper, J. L.; de la Hoya, M.; Antoniou, A. C.; Heikkinen, T.; Lee, A.; Aittomäki, K.; Blanco, I.; Lazaro, C.; Barkardottir, R. B.; Karlan, B. Y.; Soucy, P.; Dumont, M.; Terry, M. B.; Simard, J.; Montagna, M.; Registry, Breast Cancer Family; Tognazzo, S.; D'Andrea, E.; McGuffog, L.; Fox, S.; Gross, J.; Yan, M.; Rebbeck, T.; Olopade, O.; Chung, W.; Weitzel, J. N.; Lynch, H. T.; Ganz, P. A.; EMBRACE,; Tomlinson, G. E.; Wang, X.; John, E. M.; Fredericksen, Z.; Healey, S.; Pankratz, V. S.; Lindor, N. M.; Miron, A. F.; Szabo, C.; Offit, K.; Sakr, R.; Gaudet, M.; Collaborators, GEMO Study; Nielsen, F. C.; Bhatia, J.; Kauff, N.; Singer, C. F.; Tea, M. K.; Sinilnikova, O. M.; Goldgar, D.; Gschwantler-Kaulich, D.; Fink-Retter, A.; Mai, P. L.; Greene, M. H.; Daly, M. B.; Imyanitov, E.; HEBON,; O'Malley, F. P.; Ozcelik, H.; Glendon, G.; Toland, A. E.; Chenevix-Trench, G.; Gerdes, A. M.; Janavicius, R.; Thomassen, M.; Buys, S. M.; Kruse, T. A.; Jensen, U. B.; Skytte, A. B.; kConFab, Investigators; Caligo, M. A.; Soller, M.; Henriksson, K.; Easton, D. F.; Wachenfeldt, V. A.; Arver, B.; SWE-BRCA,; Stenmark-Askmalm, M.

Common breast cancer susceptibility alleles are associated with tumour subtypes in BRCA1 and BRCA2 mutation carriers: results from the Consortium of Investigators of Modifiers of BRCA1/2.

journal contribution

posted on 2012-10-24, 09:13 authored by A. M. Mulligan, F. J. Couch, D. Barrowdale, S. M. Domchek, D. Eccles, H. Nevanlinna, S. J. Ramus, M. Robson, M. Sherman, A. B. Spurdle, B. Wappenschmidt, T. V. Hansen, P. Karlsson, Y. C. Ding, S. L. Neuhausen, Ontario Cancer Genetics Network, M. Beattie, P. D. Pharoah, B. Ejlertsen, K. B. Moysich, M. C. Southey, D. Niederacher, I. L. Andrulis, I. Schoenbuchner, CIMBA, S. Mazoyer, A. Osorio, I. Coupier, I. Muñoz-Repeto, M. Durán, J. Godino, M. Pertesi, C. Sutter, J. Benítez, P. Peterlongo, B. Fiebig, S. Manoukian, B. Peissel, M. Léoné, D. Zaffaroni, E. Cattaneo, M. Lebrun, B. Bonanni, H. Deissler, A. Viel, B. Pasini, L. Papi, W. Heinritz, L. Ottini, A. Savarese, L. Bernard, N. Boutry-Kryza, P. Radice, U. Hamann, D. Gadzicki, M. Verheus, C. Kientz, H. E. Meijers-Heijboer, J. Wijnen, D. Schäfer, E. B. Gómez García, M. R. Nelen, C. M. Kets, C. Seynaeve, A. Hardouin, C. Isaacs, M. M. Tilanus-Linthorst, R. B. van der Luijt, T. van Os, M. Rookus, M. Longy, H. Gevensleben, D. Frost, J. L. Jones, D. G. Evans, F. Lalloo, K. Kast, R. Eeles, P. Berthet, L. Izatt, J. Adlard, R. Davidson, J. Cook, V. Caux-Moncoutier, A. Donaldson, N. Sevenet, H. Dorkins, S. Preisler-Adams, H. Gregory, J. Eason, C. Houghton, D. Muller, J. Barwell, L. E. Side, E. McCann, M. Fassy-Colcombet, A. Murray, S. Peock, I. Mortemousque, A. K. Godwin, D. Stoppa-Lyonnet, R. K. Schmutzler, K. Rhiem, C. Engel, J. P. Fricker, A. Meindl, I. Ruehl, T. Caldes, N. Arnold, R. Varon-Mateeva, F. Cornelis, K. L. Nathanson, P. Pujol, J. L. Hopper, M. de la Hoya, A. C. Antoniou, T. Heikkinen, A. Lee, K. Aittomäki, I. Blanco, C. Lazaro, R. B. Barkardottir, B. Y. Karlan, P. Soucy, M. Dumont, M. B. Terry, J. Simard, M. Montagna, Breast Cancer Family Registry, S. Tognazzo, E. D'Andrea, L. McGuffog, S. Fox, J. Gross, M. Yan, T. Rebbeck, O. Olopade, W. Chung, J. N. Weitzel, H. T. Lynch, P. A. Ganz, EMBRACE, G. E. Tomlinson, X. Wang, E. M. John, Z. Fredericksen, S. Healey, V. S. Pankratz, N. M. Lindor, A. F. Miron, C. Szabo, K. Offit, R. Sakr, M. Gaudet, GEMO Study Collaborators, F. C. Nielsen, J. Bhatia, N. Kauff, C. F. Singer, M. K. Tea, O. M. Sinilnikova, D. Goldgar, D. Gschwantler-Kaulich, A. Fink-Retter, P. L. Mai, M. H. Greene, M. B. Daly, E. Imyanitov, HEBON, F. P. O'Malley, H. Ozcelik, G. Glendon, A. E. Toland, G. Chenevix-Trench, A. M. Gerdes, R. Janavicius, M. Thomassen, S. M. Buys, T. A. Kruse, U. B. Jensen, A. B. Skytte, Investigators kConFab, M. A. Caligo, M. Soller, K. Henriksson, D. F. Easton, V. A. Wachenfeldt, B. Arver, SWE-BRCA, M. Stenmark-Askmalm

Previous studies have demonstrated that common breast cancer susceptibility alleles are differentially associated with breast cancer risk for BRCA1 and/or BRCA2 mutation carriers. It is currently unknown how these alleles are associated with different breast cancer subtypes in BRCA1 and BRCA2 mutation carriers defined by estrogen (ER) or progesterone receptor (PR) status of the tumour.

History

Citation

Breast Cancer Research, 2011, 13 (6), pp. R110-R110

Published in

Breast Cancer Research

Publisher

BioMed Central

eissn

1465-542X

Acceptance date

2011-11-02

Copyright date

2011

Available date

2012-10-24

Publisher DOI

https://doi.org/10.1186/bcr3052

Publisher version

http://breast-cancer-research.biomedcentral.com/articles/10.1186/bcr3052

Language

eng

Administrator link

https://leicester.figshare.com/account/articles/10117874

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Keywords

Alleles Breast Neoplasms Female Genes BRCA1 BRCA2 Genetic Predisposition to Disease Heterozygote Humans Mutation Polymorphism Single Nucleotide Receptors Estrogen Progesterone Risk

Common breast cancer susceptibility alleles are associated with tumour subtypes in BRCA1 and BRCA2 mutation carriers: results from the Consortium of Investigators of Modifiers of BRCA1/2.

History

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Acceptance date

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Available date

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Publisher version

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