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Common breast cancer susceptibility alleles are associated with tumour subtypes in BRCA1 and BRCA2 mutation carriers: results from the Consortium of Investigators of Modifiers of BRCA1/2.

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posted on 2012-10-24, 09:13 authored by A. M. Mulligan, F. J. Couch, D. Barrowdale, S. M. Domchek, D. Eccles, H. Nevanlinna, S. J. Ramus, M. Robson, M. Sherman, A. B. Spurdle, B. Wappenschmidt, T. V. Hansen, P. Karlsson, Y. C. Ding, S. L. Neuhausen, Ontario Cancer Genetics Network, M. Beattie, P. D. Pharoah, B. Ejlertsen, K. B. Moysich, M. C. Southey, D. Niederacher, I. L. Andrulis, I. Schoenbuchner, CIMBA, S. Mazoyer, A. Osorio, I. Coupier, I. Muñoz-Repeto, M. Durán, J. Godino, M. Pertesi, C. Sutter, J. Benítez, P. Peterlongo, B. Fiebig, S. Manoukian, B. Peissel, M. Léoné, D. Zaffaroni, E. Cattaneo, M. Lebrun, B. Bonanni, H. Deissler, A. Viel, B. Pasini, L. Papi, W. Heinritz, L. Ottini, A. Savarese, L. Bernard, N. Boutry-Kryza, P. Radice, U. Hamann, D. Gadzicki, M. Verheus, C. Kientz, H. E. Meijers-Heijboer, J. Wijnen, D. Schäfer, E. B. Gómez García, M. R. Nelen, C. M. Kets, C. Seynaeve, A. Hardouin, C. Isaacs, M. M. Tilanus-Linthorst, R. B. van der Luijt, T. van Os, M. Rookus, M. Longy, H. Gevensleben, D. Frost, J. L. Jones, D. G. Evans, F. Lalloo, K. Kast, R. Eeles, P. Berthet, L. Izatt, J. Adlard, R. Davidson, J. Cook, V. Caux-Moncoutier, A. Donaldson, N. Sevenet, H. Dorkins, S. Preisler-Adams, H. Gregory, J. Eason, C. Houghton, D. Muller, J. Barwell, L. E. Side, E. McCann, M. Fassy-Colcombet, A. Murray, S. Peock, I. Mortemousque, A. K. Godwin, D. Stoppa-Lyonnet, R. K. Schmutzler, K. Rhiem, C. Engel, J. P. Fricker, A. Meindl, I. Ruehl, T. Caldes, N. Arnold, R. Varon-Mateeva, F. Cornelis, K. L. Nathanson, P. Pujol, J. L. Hopper, M. de la Hoya, A. C. Antoniou, T. Heikkinen, A. Lee, K. Aittomäki, I. Blanco, C. Lazaro, R. B. Barkardottir, B. Y. Karlan, P. Soucy, M. Dumont, M. B. Terry, J. Simard, M. Montagna, Breast Cancer Family Registry, S. Tognazzo, E. D'Andrea, L. McGuffog, S. Fox, J. Gross, M. Yan, T. Rebbeck, O. Olopade, W. Chung, J. N. Weitzel, H. T. Lynch, P. A. Ganz, EMBRACE, G. E. Tomlinson, X. Wang, E. M. John, Z. Fredericksen, S. Healey, V. S. Pankratz, N. M. Lindor, A. F. Miron, C. Szabo, K. Offit, R. Sakr, M. Gaudet, GEMO Study Collaborators, F. C. Nielsen, J. Bhatia, N. Kauff, C. F. Singer, M. K. Tea, O. M. Sinilnikova, D. Goldgar, D. Gschwantler-Kaulich, A. Fink-Retter, P. L. Mai, M. H. Greene, M. B. Daly, E. Imyanitov, HEBON, F. P. O'Malley, H. Ozcelik, G. Glendon, A. E. Toland, G. Chenevix-Trench, A. M. Gerdes, R. Janavicius, M. Thomassen, S. M. Buys, T. A. Kruse, U. B. Jensen, A. B. Skytte, Investigators kConFab, M. A. Caligo, M. Soller, K. Henriksson, D. F. Easton, V. A. Wachenfeldt, B. Arver, SWE-BRCA, M. Stenmark-Askmalm
Previous studies have demonstrated that common breast cancer susceptibility alleles are differentially associated with breast cancer risk for BRCA1 and/or BRCA2 mutation carriers. It is currently unknown how these alleles are associated with different breast cancer subtypes in BRCA1 and BRCA2 mutation carriers defined by estrogen (ER) or progesterone receptor (PR) status of the tumour.

History

Citation

Breast Cancer Research, 2011, 13 (6), pp. R110-R110

Published in

Breast Cancer Research

Publisher

BioMed Central

eissn

1465-542X

Acceptance date

2011-11-02

Copyright date

2011

Available date

2012-10-24

Publisher version

http://breast-cancer-research.biomedcentral.com/articles/10.1186/bcr3052

Language

eng

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