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Comparing Characteristics of Endometrial Cancer in Women of South Asian and White Ethnicity in England

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posted on 2022-11-11, 17:08 authored by Seid Mohammed, Konstantinos Polymeros, Rochelle Wickham-Joseph, Iqra Luqman, Creana Charadva, Thomas Morris, Anna Collins, Shaun Barber, Kamlesh Khunti, Esther L Moss

Differences in patient demographic and tumour characteristics between patients of South Asian and White ethnicity diagnosed with an endometrial cancer (EC) and currently living in England are not well described. We undertook a retrospective study of EC cases diagnosed at the University Hospitals of Leicester, UK. A total of 1884 cases were included, with 13% of the patients being of South Asian ethnicity. South Asian women were diagnosed at a significantly younger age (mean age of 60.3 years) compared to women of White ethnicity (mean age of 66.9 years) with a mean difference of 6.6 years (95% CI 5.1 to 8.1, p < 0.001). Rising body mass index (BMI) in the White patient group was significantly correlated with younger age at diagnosis (p < 0.001); however, this association was not seen in South Asian patients. A linear regression that adjusted for diabetes status, BMI, and the interaction terms of diabetes status with BMI and ethnicity with BMI, highlighted a younger age of diagnosis in South Asian patients with a BMI less than 45 kg/m2. The difference was greatest at lower BMIs for both non-diabetics and diabetics. Further investigation is needed to explain these differences and to determine their impact on suspected cancer referral criteria.

Funding

Seid Mohamed was supported by Cancer Research UK in conjunction with the UK Department of Health on an Experimental Cancer Medicine Centre grant [C10604/A25151]. K.K. is supported by the National Institute for Health Research (NIHR) Applied Research Collaboration East Midlands (ARC EM) and the NIHR Leicester Biomedical Research Centre (BRC).

History

Citation

Cancers 2021, 13(23), 6123; https://doi.org/10.3390/cancers13236123

Author affiliation

Leicester Cancer Research Centre

Version

  • VoR (Version of Record)

Published in

Cancers

Volume

13

Pagination

6123

Publisher

MDPI AG

eissn

2072-6694

Acceptance date

2021-11-23

Copyright date

2021

Available date

2022-11-11

Language

en

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