DJP-CY-FT-REV-Manuscript-Jan7.pdf (1.07 MB)
Copper-catalyzed borylative multi-component synthesis of quaternary α-amino esters
journal contribution
posted on 2019-03-08, 11:49 authored by K Yeung, F Talbot, GP Howell, A Pulis, DJ ProcterCopper-catalyzed coupling of readily available ketiminoesters, allenes, and a diboron affords densely functionalized quaternary α-amino esters bearing adjacent stereocenters and versatile vinyl boronate motifs. The method utilizes a commercially available copper(I) catalyst, operates at ambient temperature, and features a catalytic allyl cupration of ketiminoesters.
Funding
We thank The University of Manchester (President’s Scholarship to K.Y. and Lectureship to A.P.P.), SCI (Scholarship to K.Y.), AstraZeneca (CASE studentship to F.J.T.T.), EPSRC (Studentship to K.Y. and F.J.T.T. and Established Career Fellowship to D.J.P.), and Dr. J.M. Suarez, Dr. S. Roland, and Prof. M. Sollogoub ((β-ICyD)CuCl).
History
Citation
ACS Catalysis, 2019, 9, 1655−1661Author affiliation
/Organisation/COLLEGE OF SCIENCE AND ENGINEERING/Department of ChemistryVersion
- AM (Accepted Manuscript)
