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Copper-catalyzed borylative multi-component synthesis of quaternary α-amino esters

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journal contribution
posted on 2019-03-08, 11:49 authored by K Yeung, F Talbot, GP Howell, A Pulis, DJ Procter
Copper-catalyzed coupling of readily available ketiminoesters, allenes, and a diboron affords densely functionalized quaternary α-amino esters bearing adjacent stereocenters and versatile vinyl boronate motifs. The method utilizes a commercially available copper(I) catalyst, operates at ambient temperature, and features a catalytic allyl cupration of ketiminoesters.

Funding

We thank The University of Manchester (President’s Scholarship to K.Y. and Lectureship to A.P.P.), SCI (Scholarship to K.Y.), AstraZeneca (CASE studentship to F.J.T.T.), EPSRC (Studentship to K.Y. and F.J.T.T. and Established Career Fellowship to D.J.P.), and Dr. J.M. Suarez, Dr. S. Roland, and Prof. M. Sollogoub ((β-ICyD)CuCl).

History

Citation

ACS Catalysis, 2019, 9, 1655−1661

Author affiliation

/Organisation/COLLEGE OF SCIENCE AND ENGINEERING/Department of Chemistry

Version

  • AM (Accepted Manuscript)

Published in

ACS Catalysis

Publisher

American Chemical Society

issn

2155-5435

Copyright date

2019

Publisher version

https://pubs.acs.org/doi/10.1021/acscatal.8b04563

Notes

The file associated with this record is under embargo until 12 months after publication, in accordance with the publisher's self-archiving policy. The full text may be available through the publisher links provided above.

Language

en

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