DJP-CY-FT-REV-Manuscript-Jan7.pdf (1.07 MB)
Copper-catalyzed borylative multi-component synthesis of quaternary α-amino esters
journal contributionposted on 2019-03-08, 11:49 authored by K Yeung, F Talbot, GP Howell, A Pulis, DJ Procter
Copper-catalyzed coupling of readily available ketiminoesters, allenes, and a diboron affords densely functionalized quaternary α-amino esters bearing adjacent stereocenters and versatile vinyl boronate motifs. The method utilizes a commercially available copper(I) catalyst, operates at ambient temperature, and features a catalytic allyl cupration of ketiminoesters.
We thank The University of Manchester (President’s Scholarship to K.Y. and Lectureship to A.P.P.), SCI (Scholarship to K.Y.), AstraZeneca (CASE studentship to F.J.T.T.), EPSRC (Studentship to K.Y. and F.J.T.T. and Established Career Fellowship to D.J.P.), and Dr. J.M. Suarez, Dr. S. Roland, and Prof. M. Sollogoub ((β-ICyD)CuCl).
CitationACS Catalysis, 2019, 9, 1655−1661
Author affiliation/Organisation/COLLEGE OF SCIENCE AND ENGINEERING/Department of Chemistry
- AM (Accepted Manuscript)