jcm-08-01377.pdf (465.12 kB)
DJ-1 in Parkinson's Disease: Clinical Insights and Therapeutic Perspectives.
journal contributionposted on 2019-09-18, 09:08 authored by Mariaelena Repici, Flaviano Giorgini
Mutations in the protein DJ-1 cause autosomal recessive forms of Parkinson's disease (PD) and oxidized DJ-1 is found in the brains of idiopathic PD individuals. While several functions have been ascribed to DJ-1 (most notably protection from oxidative stress), its contribution to PD pathogenesis is not yet clear. Here we provide an overview of the clinical research to date on DJ-1 and the current state of knowledge regarding DJ-1 characterization in the human brain. The relevance of DJ-1 as a PD biomarker is also discussed, as are studies exploring DJ-1 as a possible therapeutic target for PD and neurodegeneration.
M.R. is supported by funding from the Wellcome Trust (WT-ISSF, University of Leicester). F.G. acknowledges support from the Medical Research Council (MRC) and Parkinson’s UK for DJ-1 related research in his laboratory.
CitationJournal of Clinical Medicine, 2019, 8(9), 1377;
Author affiliation/Organisation/COLLEGE OF LIFE SCIENCES/Biological Sciences/Genetics and Genome Biology
- VoR (Version of Record)