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Danavorexton (TAK-925): an orexin receptor 2 agonist as a new ‘arousal’ agent

Version 2 2025-02-04, 16:06
Version 1 2025-01-29, 16:09
journal contribution
posted on 2025-02-04, 16:06 authored by David G Lambert, Kazuyoshi Hirota
A preclinical study in animals has further characterised a new ‘arousal’ agent. Danavorexton (TAK-925) is an agonist for orexin receptor 2 where it promotes recovery from inhalational and i.v. anaesthesia and opioid sedation. Although danavorexton reverses opioid sedation, it does not compromise analgesia. This could be a useful addition to the postoperative drug cupboard.

History

Author affiliation

College of Life Sciences Cardiovascular Sciences

Version

  • VoR (Version of Record)

Published in

British Journal of Anaesthesia

Volume

132

Issue

3

Pagination

466 - 468

Publisher

Elsevier BV

issn

0007-0912

eissn

1471-6771

Copyright date

2025

Notes

Editorial

Spatial coverage

England

Language

en

Deposited by

Professor David Lambert

Deposit date

2025-01-13

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