Deleted in malignant brain tumor 1 genetic variation confers urinary tract infection risk in children and mice
journal contribution
posted on 2022-05-06, 11:04 authored by David S Hains, Shamik Polley, Dong Liang, Vijay Saxena, Samuel Arregui, John Ketz, Evan Barr-Beare, Ashley Rawson, John D Spencer, Ariel Cohen, Pernille L Hansen, Martina Tuttolomondo, Cinzia Casella, Henrik J Ditzel, Daniel Cohen, Edward J Hollox, Andrew L SchwadererLetter to Editor: We identify that children with a history of urinary tract infections (UTIs) and vesicoureteral reflux (VUR) with low deleted in Malignant Brain Tumors 1 (DMBT1) DNA copy number have ∼4‐fold higher odds of recurrent UTIs compared to those with high DMBT1 DNA copy number. With bacterial resistance to antibiotics increasing, we need to develop new strategies to guide judicious use of antibiotics such as using the patient's genetic profile.
Funding
The work was supported by grants from the United States National Institutes of Health (NIDDK), (grant numbers: R01DK106286 and 1RC4DK090937).
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Citation
Hains DS, Polley S, Liang D, Saxena V, Arregui S, Ketz J, Barr-Beare E, Rawson A, Spencer JD, Cohen A, Hansen PL, Tuttolomondo M, Casella C, Ditzel HJ, Cohen D, Hollox EJ, Schwaderer AL. Deleted in malignant brain tumor 1 genetic variation confers urinary tract infection risk in children and mice. Clin Transl Med. 2021 Jul;11(7):e477. doi: 10.1002/ctm2.477.Author affiliation
Department of Genetics and Genome BiologyVersion
- VoR (Version of Record)
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Clinical and Translational MedicineVolume
11Issue
7Pagination
e477Publisher
Wiley Open Accessissn
2001-1326eissn
2001-1326Acceptance date
2021-06-08Copyright date
2021Available date
2021-07-04Publisher DOI
Language
EnglishPublisher version
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