Deleted in malignant brain tumor 1 genetic variation confers urinary tract infection risk in children and mice
journal contribution
posted on 2022-05-06, 11:04 authored by David S Hains, Shamik Polley, Dong Liang, Vijay Saxena, Samuel Arregui, John Ketz, Evan Barr-Beare, Ashley Rawson, John D Spencer, Ariel Cohen, Pernille L Hansen, Martina Tuttolomondo, Cinzia Casella, Henrik J Ditzel, Daniel Cohen, Edward J Hollox, Andrew L Schwaderer<p>Letter to Editor: We identify that children with a history of urinary tract infections (UTIs) and vesicoureteral reflux (VUR) with low deleted in Malignant Brain Tumors 1 (<em>DMBT1</em>) DNA copy number have ∼4‐fold higher odds of recurrent UTIs compared to those with high <em>DMBT1</em> DNA copy number. With bacterial resistance to antibiotics increasing, we need to develop new strategies to guide judicious use of antibiotics such as using the patient's genetic profile.</p>
Funding
The work was supported by grants from the United States National Institutes of Health (NIDDK), (grant numbers: R01DK106286 and 1RC4DK090937).
History
Citation
Hains DS, Polley S, Liang D, Saxena V, Arregui S, Ketz J, Barr-Beare E, Rawson A, Spencer JD, Cohen A, Hansen PL, Tuttolomondo M, Casella C, Ditzel HJ, Cohen D, Hollox EJ, Schwaderer AL. Deleted in malignant brain tumor 1 genetic variation confers urinary tract infection risk in children and mice. Clin Transl Med. 2021 Jul;11(7):e477. doi: 10.1002/ctm2.477.Author affiliation
Department of Genetics and Genome BiologyVersion
- VoR (Version of Record)
Published in
Clinical and Translational MedicineVolume
11Issue
7Pagination
e477Publisher
Wiley Open Accessissn
2001-1326eissn
2001-1326Acceptance date
2021-06-08Copyright date
2021Available date
2021-07-04Publisher DOI
Language
EnglishPublisher version
Usage metrics
Categories
No categories selectedKeywords
Licence
Exports
RefWorks
BibTeX
Ref. manager
Endnote
DataCite
NLM
DC