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Deleterious Mutation Accumulation in Arabidopsis thaliana Pollen Genes: A Role for a Recent Relaxation of Selection.pdf (814.55 kB)

Deleterious Mutation Accumulation in Arabidopsis thaliana Pollen Genes: A Role for a Recent Relaxation of Selection.

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posted on 2019-08-07, 08:43 authored by Mark C. Harrison, Eamonn B. Mallon, Dave Twell, Robert L. Hammond
In many studies, sex-related genes have been found to evolve rapidly. We therefore expect plant pollen genes to evolve faster than sporophytic genes. In addition, pollen genes are expressed as haploids which can itself facilitate rapid evolution because recessive advantageous and deleterious alleles are not masked by dominant alleles. However, this mechanism is less straightforward to apply in the model plant species Arabidopsis thaliana. For 1 Myr, A. thaliana has been self-compatible, a life history switch that has caused: a reduction in pollen competition, increased homozygosity, and a dilution of masking in diploid expressed, sporophytic genes. In this study, we have investigated the relative strength of selection on pollen genes compared with sporophytic genes in A. thaliana. We present two major findings: 1) before becoming self-compatible, positive selection was stronger on pollen genes than sporophytic genes for A. thaliana and 2) current polymorphism data indicate that selection is weaker on pollen genes compared with sporophytic genes. This weaker selection on pollen genes can in part be explained by their higher tissue specificity, which in outbreeding plants can be outweighed by the effects of haploid expression and pollen competition. These results indicate that since A. thaliana has become self-compatible, selection on pollen genes has become more relaxed. This has led to higher polymorphism levels and a higher build-up of deleterious mutations in pollen genes compared with sporophytic genes.

Funding

M.C.H. was supported by a PhD research grant from the Natural Environment Research Council (NERC). D.T. would like to acknowledge financial support from the UK Biotechnology and Biological Science Research Council (BBSRC).

History

Citation

Genome Biology and Evolution, 2019, Volume 11, Issue 7, Pages 1939–1951

Author affiliation

/Organisation/COLLEGE OF LIFE SCIENCES/Biological Sciences/Genetics and Genome Biology

Version

  • VoR (Version of Record)

Published in

Genome Biology and Evolution

Publisher

Oxford University Press (OUP) for Society for Molecular Biology and Evolution

eissn

1759-6653

Acceptance date

2019-06-11

Copyright date

2019

Available date

2019-08-07

Publisher version

https://academic.oup.com/gbe/article/11/7/1939/5519772

Notes

Supplementary data are available at Genome Biology and Evolution online. https://academic.oup.com/gbe/article/11/7/1939/5519772#supplementary-data All custom made scripts used in this study are deposited at the following dedicated GitHub site: https://github.com/MarkChristianHarrison/PloidyAndSelection.git.

Language

en

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