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Detection of multiple fluorescent labels using superconducting tunnel junction detectors.
journal contributionposted on 2007-05-30, 11:25 authored by G. W. Fraser, J. S. (Pat) Heslop-Harrison, T. Schwarzacher, A. D. Holland, P. Verhoeve, A. Peacock
We show that cryogenically cooled, photon counting superconducting tunnel junctions ~STJs! can be used to simultaneously record the optical spectra from multiple biological fluorochromes. Measurements with a single-pixel tantalum STJ with a wavelength resolving power R5l/Dl of about 10 confirm the expected sensitivity advantage with respect to the photomultiplier-based detectors commonly used to record signals from microarrays and other fluorescent biological systems.