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Diabetic peripheral neuropathy: advances in diagnosis and strategies for screening and early intervention

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journal contribution
posted on 2020-04-20, 08:10 authored by D selvarajah, D Kar, Kamlesh Khunti, Melanie J. Davies, A Scott, J Walker, S Tesfaye
Diabetic peripheral neuropathy (DPN) is a common complication of both type 1 and 2 diabetes. It is a leading cause of lower-limb amputation and disabling neuropathic pain. Amputations in patients with diabetes have a devastating effect on quality of life and are associated with an alarmingly low life expectancy (on average only 2 years from the amputation). Amputation also places a substantial financial burden on health-care systems and society in general. With the introduction of national diabetes eye screening programmes, the prevalence of blindness in working-age adults is falling. This is not the case, however, with diabetes related amputations. In this Review, we appraise innovative point-of-care devices that enable the early diagnosis of DPN and assess the evidence for early risk factor-based management strategies to reduce the incidence and slow the progression of DPN. We also propose a framework for screening and early multifactorial interventions as the best prospect for preventing or halting DPN and its devastating sequelae.

History

Citation

Lancet Diabetes and Endocrinology, 2019, 7 (12), pp. 938-948

Author affiliation

/Organisation/COLLEGE OF LIFE SCIENCES/School of Medicine/Diabetes Research Centre

Version

  • AM (Accepted Manuscript)

Published in

Lancet Diabetes and Endocrinology

Volume

7

Issue

12

Pagination

938-948

Publisher

Elsevier

issn

2213-8587

Acceptance date

2019-01-03

Copyright date

2019

Available date

2020-04-14

Publisher version

https://www.clinicalkey.com/#!/content/playContent/1-s2.0-S2213858719300816?returnurl=https://linkinghub.elsevier.com/retrieve/pii/S2213858719300816?showall=true&referrer=

Language

en

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