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Dietary fat in relation to fatty acid composition of red cells and adipose tissue in colorectal cancer

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posted on 2016-12-13, 16:00 authored by J. P. Neoptolemos, H. Clayton, A. M. Heagerty, M. J. Nicholson, B. Johnson, J. Mason, K. Manson, R. F. L. James, P. R. F. Bell
Fatty acids were determined in erthrocytes in 49 patients with colorectal cancer and compared with age and sex-matched controls. Marginally increased levels of stearic acid (P = 0.057) and oleic acid (P = 0.064) and decreased arachidonic acid (P = 0.043) occurred in cancer patients. There was no difference in the stearic to oleic acid ratio between the two groups. Dietary intake, assessed by dietary recall and adipose tissue analysis was also not different. In control subjects the polyunsaturated:saturated (P:S) fatty acid ratio correlated between diet and adipose tissue (P less than 0.01, at least). In contrast cancer patients showed different correlations; in particular dietary and erythrocyte P:S fatty acid ratios correlated (P less than 0.01). These findings may indicate disturbed fat metabolism in cancer patients. The erythrocyte stearic to oleic acid ratio is of no diagnostic value.

Funding

This work was supported by a grant from the Trent Regional Health Authority.

History

Citation

British Journal of Cancer, (1988) 58, 575–579.

Author affiliation

/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGY/School of Medicine/Department of Infection, Immunity and Inflammation

Version

  • VoR (Version of Record)

Published in

British Journal of Cancer

Publisher

Cancer Research UK

issn

0007-0920

eissn

1532-1827

Available date

2016-12-13

Publisher version

http://www.nature.com/bjc/journal/v58/n5/abs/bjc1988262a.html

Language

en

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