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Differences in the molecular profile of endometrial cancers from British White and British South Asian women

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posted on 2020-07-29, 10:50 authored by K Polymeros, DS Guttery, R Hew, R Bishop, E Stannard, S Macip, P Symonds, EL Moss
OBJECTIVES: To identify differences in the mutational profile of endometrial tumours between British White (BW) and South Asian (BSA) women. METHODS: We analysed primary tumours from matched cohorts of British White (BW) and British South Asian (BSA) women resident in Leicestershire diagnosed with EC. Next Generation Sequencing was performed to investigate mutational differences in a panel of 10 genes previously identified as being commonly mutated in EC. The presence of somatic Mismatch Repair (MMR) gene deficiencies was determined by immunohistochemistry.

RESULTS: In total, 57 tumours (27 BSA and 30 BW) were sequenced. There was no significant difference in the overall mutation frequency of the 10 genes analysed; however, numerous differences were observed between the groups. There was a positive association between PIK3CA and PTEN mutations in the BSA group, with 78% of PIK3CA-mutant tumours harbouring a PTEN mutation, whereas only 11% of PIK3CA wild-type (wt) tumours were PTEN mutant positive (p = 0.0012). In BW women, 90% of ARID1A mutant tumours had co-existent PI3K pathway mutations versus 50% of wild-type (wt) ARID1A patients (p = 0.0485). This trend was not significant in the BSA group (p = 0.66). The age at diagnosis was significantly higher in the BW group with a somatic MMR gene deficiency compared to those with no deficiency (72.8 years versus 59.6 years, p = 0.007), whereas this difference was not seen in the BSA group (64 years versus 60 years, p = 0.37).

CONCLUSION: We have identified differences in the mutational profile of primary EC tumours from BW and BSA women. Further research is needed to confirm these findings and to explore their potential implications for early detection, treatment response and prognosis.

Funding

EM received funding from Cancer Research UK (https://www.cancerresearchuk.org/, grant code C1362/A18081) and the charity Hope Against Cancer (https://www.hopeagainstcancer.org.uk/, grant code RM60G0579).

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Citation

Differences in the molecular profile of endometrial cancers from British White and British South Asian women Polymeros K, Guttery DS, Hew R, Bishop R, Stannard E, et al. (2020) Differences in the molecular profile of endometrial cancers from British White and British South Asian women. PLOS ONE 15(6): e0233900. https://doi.org/10.1371/journal.pone.0233900

Published in

PLoS One

Volume

15

Issue

6

Pagination

e0233900

Publisher

Public Library of Science

issn

1932-6203

eissn

1932-6203

Acceptance date

2020-05-15

Copyright date

2020

Available date

2020-07-29

Spatial coverage

United States

Language

eng

Publisher version

https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0233900

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