University of Leicester
Browse

Differential expression of functional chemokine receptors on human blood and lung group 2 innate lymphoid cells.

Download (1.94 MB)
journal contribution
posted on 2019-02-08, 10:53 authored by CA Weston, BMJ Rana, DJ Cousins
[First paragraph] Innate lymphoid cells (ILCs), primarily found at mucosal barriers, provide immediate protection against the establishment and spread of infection. ILCs have been divided into 3 subsets analogous to TH cells1: ILC1, ILC2, and ILC3. ILC2s are similar to TH2 cells and express IL-4, IL-5, and IL-13 and were initially identified as a non–T-, non–B-cell source of type 2 cytokines.2 They are found in the blood, gut, skin, and lung where they contribute to host defence. Upon activation, ILCs rapidly produce a large quantity of cytokines and other mediators, which attract and activate other inflammatory cells. In various models of airway disease, ILC2 numbers have been shown to increase with allergen challenge, leading to a significant increase in type 2 inflammatory cytokines.3 Recent studies have demonstrated the existence of a complex interplay between lung epithelial cells and ILC2s that is required for asthma persistence in a mouse model. Furthermore, human studies have suggested that ILC2s provide the key link between viral infection and airway inflammation leading to asthma exacerbations.

History

Citation

Journal of Allergy and Clinical Immunology, 2019, 143(1), pp. 410-413.e9

Author affiliation

/Organisation/COLLEGE OF LIFE SCIENCES/School of Medicine/Department of Infection, Immunity and Inflammation

Version

  • VoR (Version of Record)

Published in

Journal of Allergy and Clinical Immunology

Publisher

Elsevier for American Academy of Allergy, Asthma and Immunology, Mosby

eissn

1097-6825

Acceptance date

2018-08-24

Copyright date

2018

Available date

2019-02-08

Publisher version

https://www.sciencedirect.com/science/article/pii/S0091674918312764?via=ihub

Language

en

Usage metrics

    University of Leicester Publications

    Categories

    No categories selected

    Keywords

    Licence

    Exports

    RefWorks
    BibTeX
    Ref. manager
    Endnote
    DataCite
    NLM
    DC