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Differential expression of immune defences is associated with specific host-parasite interactions in insects.

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posted on 2012-10-24, 08:58 authored by Carolyn Riddell, S. Adams, P. Schmid-Hempel, Eamonn B. Mallon
Recent ecological studies in invertebrates show that the outcome of an infection is dependent on the specific pairing of host and parasite. Such specificity contrasts the long-held view that invertebrate innate immunity depends on a broad-spectrum recognition system. An important question is whether this specificity is due to the immune response rather than some other interplay between host and parasite genotypes. By measuring the expression of putative bumblebee homologues of antimicrobial peptides in response to infection by their gut trypanosome Crithidia bombi, we demonstrate that expression differences are associated with the specific interactions. Recent ecological studies in invertebrates show that the outcome of an infection is dependent on the specific pairing of host and parasite. Such specificity contrasts the long-held view that invertebrate innate immunity depends on a broad-spectrum recognition system. An important question is whether this specificity is due to the immune response rather than some other interplay between host and parasite genotypes. By measuring the expression of putative bumblebee homologues of antimicrobial peptides in response to infection by their gut trypanosome Crithidia bombi, we demonstrate that expression differences are associated with the specific interactions.

Funding

CR was supported by a BBSRC studentship. SA was supported by a research grant from the British Ecological Society. This work was funded by a research grant from the Royal Society.

History

Citation

PLoS ONE, 2009, 4 (10), pp. e7621-e7621

Published in

PLoS ONE

Publisher

Public Library of Science

issn

1932-6203

eissn

1932-6203

Copyright date

2009

Available date

2012-10-24

Publisher version

http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0007621

Notes

Supplementary Material S1 Found at: doi:10.1371/journal.pone.0007621.s001 (0.05 MB DOC)

Language

eng